3OTF
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![BU of 3otf by Molmil](/molmil-images/mine/3otf) | Structural basis for the cAMP-dependent gating in human HCN4 channel | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Authors: | Xu, X, Vysotskaya, Z.V, Liu, Q, Zhou, L. | Deposit date: | 2010-09-11 | Release date: | 2010-10-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for the cAMP-dependent gating in the human HCN4 channel. J.Biol.Chem., 285, 2010
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4DJC
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![BU of 4djc by Molmil](/molmil-images/mine/4djc) | 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex | Descriptor: | CALCIUM ION, Calmodulin, ISOPROPYL ALCOHOL, ... | Authors: | Sarhan, M.F, Tung, C.-C, Van Petegem, F, Ahern, C.A. | Deposit date: | 2012-02-01 | Release date: | 2012-02-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Crystallographic basis for calcium regulation of sodium channels. Proc.Natl.Acad.Sci.USA, 109, 2012
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6DAE
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6DAD
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![BU of 6dad by Molmil](/molmil-images/mine/6dad) | 1.65 Angstrom crystal structure of the N97I Ca/CaM:CaV1.2 IQ domain complex | Descriptor: | CALCIUM ION, Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C | Authors: | Wang, K, Van Petegem, F. | Deposit date: | 2018-05-01 | Release date: | 2018-10-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4HBN
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![BU of 4hbn by Molmil](/molmil-images/mine/4hbn) | Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PHOSPHATE ION, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Authors: | Xu, X, Marni, F, Wu, X, Su, Z, Musayev, F, Shrestha, S, Xie, C, Gao, W, Liu, Q, Zhou, L. | Deposit date: | 2012-09-28 | Release date: | 2013-01-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Local and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel. Structure, 20, 2012
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1ROO
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![BU of 1roo by Molmil](/molmil-images/mine/1roo) | NMR SOLUTION STRUCTURE OF SHK TOXIN, NMR, 20 STRUCTURES | Descriptor: | SHK TOXIN | Authors: | Tudor, J.E, Pallaghy, P.K, Pennington, M.W, Norton, R.S. | Deposit date: | 1996-01-11 | Release date: | 1997-01-27 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone. Nat.Struct.Biol., 3, 1996
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3U10
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![BU of 3u10 by Molmil](/molmil-images/mine/3u10) | Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Authors: | Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A. | Deposit date: | 2011-09-29 | Release date: | 2011-10-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J.Biol.Chem., 286, 2011
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6E2G
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6E2F
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6MC9
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6MBA
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![BU of 6mba by Molmil](/molmil-images/mine/6mba) | Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CARBONATE ION, ... | Authors: | Yoder, J, Gabelli, S.B, Amzel, L.M. | Deposit date: | 2018-08-29 | Release date: | 2019-04-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. Nat Commun, 10, 2019
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7YO4
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1WVR
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![BU of 1wvr by Molmil](/molmil-images/mine/1wvr) | Crystal Structure of a CRISP family Ca-channel blocker derived from snake venom | Descriptor: | CADMIUM ION, Triflin | Authors: | Shikamoto, Y, Suto, K, Yamazaki, Y, Morita, T, Mizuno, H. | Deposit date: | 2004-12-24 | Release date: | 2005-07-05 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of a CRISP family Ca2+ -channel blocker derived from snake venom. J.Mol.Biol., 350, 2005
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2F3Y
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![BU of 2f3y by Molmil](/molmil-images/mine/2f3y) | Calmodulin/IQ domain complex | Descriptor: | CALCIUM ION, Calmodulin, MAGNESIUM ION, ... | Authors: | Fallon, J.L, Quiocho, F.A. | Deposit date: | 2005-11-22 | Release date: | 2005-12-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure of Calmodulin Bound to the Hydrophobic IQ Domain of the Cardiac Ca(v)1.2 Calcium Channel. Structure, 13, 2005
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2F3Z
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![BU of 2f3z by Molmil](/molmil-images/mine/2f3z) | Calmodulin/IQ-AA domain complex | Descriptor: | CALCIUM ION, Calmodulin, Voltage-dependent L-type calcium channel alpha-1C subunit | Authors: | Fallon, J.L, Quiocho, F.A. | Deposit date: | 2005-11-22 | Release date: | 2005-12-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of Calmodulin Bound to the Hydrophobic IQ Domain of the Cardiac Ca(v)1.2 Calcium Channel. Structure, 13, 2005
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3G43
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7UDV
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7YO3
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7YO0
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![BU of 7yo0 by Molmil](/molmil-images/mine/7yo0) | Cryo-EM structure of human Slo1-LRRC26 complex with Symmetry Expansion | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, Calcium-activated potassium channel subunit alpha-1, ... | Authors: | Yamanouchi, D, Nureki, O. | Deposit date: | 2022-08-01 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for dual allosteric gating modulation of Slo1-LRRC channel complex To Be Published
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7YNZ
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7YO1
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2MHF
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3U11
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![BU of 3u11 by Molmil](/molmil-images/mine/3u11) | Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Authors: | Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A. | Deposit date: | 2011-09-29 | Release date: | 2011-10-26 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J.Biol.Chem., 286, 2011
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3TLW
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![BU of 3tlw by Molmil](/molmil-images/mine/3tlw) | The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' oxidized mutant in a locally-closed conformation (LC2 subtype) | Descriptor: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Glr4197 protein | Authors: | Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. | Deposit date: | 2011-08-30 | Release date: | 2012-05-16 | Last modified: | 2012-06-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012
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3TLT
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![BU of 3tlt by Molmil](/molmil-images/mine/3tlt) | The GLIC pentameric Ligand-Gated Ion Channel H11'F mutant in a locally-closed conformation (LC1 subtype) | Descriptor: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Glr4197 protein | Authors: | Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. | Deposit date: | 2011-08-30 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012
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