6MC9

Crystal Structure of Human Nav1.4 C-Terminal (1599-1754) domain in complex with calcium-bound calmodulin

Summary for 6MC9

Entry DOI	10.2210/pdb6mc9/pdb
Descriptor	Sodium channel protein type 4 subunit alpha, Calmodulin-1, CALCIUM ION (3 entities in total)
Functional Keywords	scn4a, voltage gated sodium channel, calmodulin, calmodulin-binding protein, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	36224.80
Authors	Yoder, J.B.,Gabelli, S.B.,Amzel, L.M. (deposition date: 2018-08-30, release date: 2019-04-10, Last modification date: 2023-10-11)
Primary citation	Yoder, J.B.,Ben-Johny, M.,Farinelli, F.,Srinivasan, L.,Shoemaker, S.R.,Tomaselli, G.F.,Gabelli, S.B.,Amzel, L.M. Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. Nat Commun, 10:1514-1514, 2019 Cited by PubMed: 30944319 DOI: 10.1038/s41467-019-09570-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation