6MBA

Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin

Summary for 6MBA

Entry DOI	10.2210/pdb6mba/pdb
Descriptor	Sodium channel protein type 4 subunit alpha, Calmodulin-1, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	scn4a, voltage gated sodium channel, calmodulin, membrane protein, calmodulin-binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	36845.76
Authors	Yoder, J.,Gabelli, S.B.,Amzel, L.M. (deposition date: 2018-08-29, release date: 2019-04-10, Last modification date: 2023-10-11)
Primary citation	Yoder, J.B.,Ben-Johny, M.,Farinelli, F.,Srinivasan, L.,Shoemaker, S.R.,Tomaselli, G.F.,Gabelli, S.B.,Amzel, L.M. Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. Nat Commun, 10:1514-1514, 2019 Cited by PubMed: 30944319 DOI: 10.1038/s41467-019-09570-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.799 Å)

Structure validation