3HPQ
 
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7FC9
 | | Crystal structure of CmABCB1 in lipidic mesophase revealed by LCP-SFX | | Descriptor: | ACETATE ION, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Pan, D, Oyama, R, Sato, T, Nakane, T, Mizunuma, R, Matsuoka, K, Joti, Y, Tono, K, Nango, E, Iwata, S, Nakatsu, T, Kato, H. | | Deposit date: | 2021-07-14 | | Release date: | 2022-02-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX.
Iucrj, 9, 2022
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8JEL
 | | Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I | | Descriptor: | T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain | | Authors: | Sun, J, Zhang, X.X, Song, J. | | Deposit date: | 2023-05-16 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.
Structure, 32, 2024
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8JEQ
 | | Crystal structure of Tiragolumab | | Descriptor: | antibody heavy chain, antibody light chain | | Authors: | Sun, J, Zhang, X.X, Song, J. | | Deposit date: | 2023-05-16 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.
Structure, 32, 2024
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8JEO
 | | Crystal structure of TIGIT in complexed with Tiragolumab | | Descriptor: | T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain | | Authors: | Sun, J, Zhang, X.X, Song, J. | | Deposit date: | 2023-05-16 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.
Structure, 32, 2024
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8JEN
 | | Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II | | Descriptor: | T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain | | Authors: | Sun, J, Zhang, X.X, Song, J. | | Deposit date: | 2023-05-16 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.
Structure, 32, 2024
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8JEP
 | | Crystal structure of Ociperlimab | | Descriptor: | antibody heavy chain, antibody light chain | | Authors: | Sun, J, Zhang, X.X, Song, J. | | Deposit date: | 2023-05-16 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.
Structure, 32, 2024
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5WE3
 | | Solution NMR structure of PaurTx-3 | | Descriptor: | Beta-theraphotoxin-Ps1a | | Authors: | Agwa, A.J, Schroeder, C.I. | | Deposit date: | 2017-07-06 | | Release date: | 2017-09-13 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins.
Toxins (Basel), 9, 2017
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7TIJ
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7THY
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7TZO
 | | The apo structure of human mTORC2 complex | | Descriptor: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | | Authors: | Yu, Z, Chen, J, Pearce, D. | | Deposit date: | 2022-02-16 | | Release date: | 2023-01-11 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
J.Biol.Chem., 298, 2022
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6DK9
 | | Yeast Ddi2 Cyanamide Hydratase | | Descriptor: | DNA damage-inducible protein, SULFATE ION, ZINC ION | | Authors: | Moore, S.A, Xiao, W, Li, J. | | Deposit date: | 2018-05-29 | | Release date: | 2019-05-08 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of Ddi2, a highly inducible detoxifying metalloenzyme fromSaccharomyces cerevisiae.
J.Biol.Chem., 294, 2019
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2HNT
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8JGS
 | | Cryo-EM structure of apo state mClC-3_I607T | | Descriptor: | H(+)/Cl(-) exchange transporter 3 | | Authors: | Wan, Y.Z.Q, Yang, F. | | Deposit date: | 2023-05-21 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
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8JGV
 | | Cryo-EM structure of mClC-3_I607T with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, H(+)/Cl(-) exchange transporter 3 | | Authors: | Wan, Y.Z.Q, Yang, F. | | Deposit date: | 2023-05-21 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
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8JGL
 | | Cryo-EM structure of mClC-3 with AMP | | Descriptor: | ADENOSINE MONOPHOSPHATE, H(+)/Cl(-) exchange transporter 3 | | Authors: | Wan, Y.Z.Q, Yang, F. | | Deposit date: | 2023-05-21 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
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8KB5
 | | Cryo-EM structure of the human nucleosome containing H3.8 | | Descriptor: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | Authors: | Hirai, H, Kujirai, T, Takizawa, Y, Kurumizaka, H. | | Deposit date: | 2023-08-03 | | Release date: | 2023-10-18 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.26133 Å) | | Cite: | Cryo-EM and biochemical analyses of the nucleosome containing the human histone H3 variant H3.8.
J.Biochem., 174, 2023
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8K9G
 | | Cryo-EM structure of Crt-SPARTA-gRNA-tDNA dimer (conformation-1) | | Descriptor: | DNA (45-mer), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*U)-3'), ... | | Authors: | Gao, X, Shang, K, Zhu, K, Wang, L, Mu, Z, Fu, X, Yu, X, Qin, B, Zhu, H, Ding, W, Cui, S. | | Deposit date: | 2023-08-01 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute.
Nature, 625, 2024
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8KHP
 | | CULLIN3-KLHL22-RBX1 E3 ligase | | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch-like protein 22 | | Authors: | Su, M.-Y, Su, M.-Y. | | Deposit date: | 2023-08-22 | | Release date: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (3.67 Å) | | Cite: | Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme.
Structure, 31, 2023
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8K34
 | | Cryo-EM structure of SPARTA gRNA binary complex | | Descriptor: | MAGNESIUM ION, Piwi domain-containing protein, RNA (5'-R(P*AP*AP*AP*CP*GP*GP*CP*UP*CP*UP*AP*AP*UP*CP*UP*AP*UP*UP*AP*GP*U)-3'), ... | | Authors: | Zhang, J.T, Jia, N. | | Deposit date: | 2023-07-14 | | Release date: | 2024-01-17 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system.
Nat.Chem.Biol., 20, 2024
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8JU7
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8KFX
 | | Gi bound CCR8 complex with nonpeptide agonist LMD-009 | | Descriptor: | 8-[[3-(2-methoxyphenoxy)phenyl]methyl]-1-(2-phenylethyl)-1,3,8-triazaspiro[4.5]decan-4-one, C-C chemokine receptor type 8,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Jiang, S, Lin, X, Wu, L.J, Xu, F. | | Deposit date: | 2023-08-16 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8.
Sci Adv, 10, 2024
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8KFZ
 | | Gi bound CCR8 in ligand free state | | Descriptor: | C-C chemokine receptor type 8,LgBiT fusion protein,Recombinant Human Rhinovirus, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Jiang, S, Lin, X, Wu, L.J, Xu, F. | | Deposit date: | 2023-08-16 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8.
Sci Adv, 10, 2024
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8KFY
 | | Gi bound CCR8 complex with nonpeptide agonist ZK 756326 | | Descriptor: | 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol, C-C chemokine receptor type 8,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Jiang, S, Lin, X, Wu, L.J, Xu, F. | | Deposit date: | 2023-08-16 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8.
Sci Adv, 10, 2024
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8KDX
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