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7THY

Structure of Leucine Rich Repeat Kinase 2's ROC domain interacting with the microtubule facing the minus end

Summary for 7THY
Entry DOI10.2210/pdb7thy/pdb
EMDB information25649 25658 25897 25906
DescriptorLeucine-rich repeat serine/threonine-protein kinase 2, GUANOSINE-5'-DIPHOSPHATE (2 entities in total)
Functional Keywordsparkinson's disease, microtubule, kinase, gtpase, cytosolic protein
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight22634.96
Authors
Matyszewski, M.,Leschziner, A.E. (deposition date: 2022-01-12, release date: 2022-12-28)
Primary citationSnead, D.M.,Matyszewski, M.,Dickey, A.M.,Lin, Y.X.,Leschziner, A.E.,Reck-Peterson, S.L.
Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules.
Nat.Struct.Mol.Biol., 29:1196-1207, 2022
Cited by
PubMed: 36510024
DOI: 10.1038/s41594-022-00863-y
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (5.2 Å)
Structure validation

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