8JEN

Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II

Summary for 8JEN

Entry DOI	10.2210/pdb8jen/pdb
Descriptor	antibody heavy chain, antibody light chain, T-cell immunoreceptor with Ig and ITIM domains, ... (4 entities in total)
Functional Keywords	immunotherapy, antibody, checkpoint inhibitor, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	12
Total formula weight	239386.83
Authors	Sun, J.,Zhang, X.X.,Song, J. (deposition date: 2023-05-16, release date: 2024-02-28, Last modification date: 2024-03-20)
Primary citation	Sun, J.,Zhang, X.,Xue, L.,Cheng, L.,Zhang, J.,Chen, X.,Shen, Z.,Li, K.,Wang, L.,Huang, C.,Song, J. Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 2024 Cited by PubMed: 38460520 DOI: 10.1016/j.str.2024.02.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.71 Å)

Structure validation