8JEN

Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, K (A, C, E, G)	antibody heavy chain	polymer	222	23784.6	4		Homo sapiens (human)
2	B, D, F, L (B, D, F, H)	antibody light chain	polymer	214	23302.9	4		Homo sapiens (human)
3	G, H, I, J (I, J, M, P)	T-cell immunoreceptor with Ig and ITIM domains	polymer	115	12759.2	4	UniProt (Q495A1) Pfam (PF07686)	Homo sapiens (human)	V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3
4	M, N, O, P, Q... (A, B, C, D, E...)	water	water		18.0	395	Chemie (HOH)

Sequence modifications

I, J, M, P: 22 - 128 (UniProt: Q495A1)

PDB	External Database	Details
Leu 129	-	expression tag
Glu 130	-	expression tag
His 131	-	expression tag
His 132	-	expression tag
His 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	239386.8
All*	Total formula weight	239386.8

*Water molecules are not included.