8JEO

Crystal structure of TIGIT in complexed with Tiragolumab

Summary for 8JEO

• Entry DOI: 10.2210/pdb8jeo/pdb
• Descriptor: T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain, ... (4 entities in total)
• Functional Keywords: immunotherapy, antibody, checkpoint inhibitor, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 124832.78

Authors

Sun, J.,Zhang, X.X.,Song, J. (deposition date: 2023-05-16, release date: 2024-02-28, Last modification date: 2024-03-20)

• Primary citation: Sun, J.,Zhang, X.,Xue, L.,Cheng, L.,Zhang, J.,Chen, X.,Shen, Z.,Li, K.,Wang, L.,Huang, C.,Song, J.; Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.; Structure, 2024; PubMed: 38460520; DOI: 10.1016/j.str.2024.02.009

Experimental method

X-RAY DIFFRACTION (2.06 Å)