8JEO

Crystal structure of TIGIT in complexed with Tiragolumab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	T-cell immunoreceptor with Ig and ITIM domains	polymer	115	12759.2	2	UniProt (Q495A1) Pfam (PF07686) In PDB	Homo sapiens (human)	V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3
2	B, E	antibody heavy chain	polymer	235	25410.3	2		Homo sapiens (human)
3	C, F	antibody light chain	polymer	220	24246.9	2		Homo sapiens (human)
4		water	water		18.0	682	Chemie (HOH)

Sequence modifications

A, D: 22 - 128 (UniProt: Q495A1)

PDB	External Database	Details
Leu 129	-	expression tag
Glu 130	-	expression tag
His 131	-	expression tag
His 132	-	expression tag
His 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	124832.8
All*	Total formula weight	124832.8

*Water molecules are not included.