Crystal structure of wild-type adenylate kinase from E. coli, in complex with Ap5A

Summary for 3HPQ

DescriptorAdenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE (3 entities in total)
Functional Keywordsenzyme inhibitor complex, atp-binding, kinase, nucleotide biosynthesis, nucleotide-binding, transferase
Biological sourceEscherichia coli
Cellular locationCytoplasm P69441
Total number of polymer chains2
Total molecular weight49072.79
Hilser, V.J.,Travis, T.P.,Bolen, D.W. (deposition date: 2009-06-04, release date: 2009-11-03, Last modification date: 2011-07-13)
Primary citation
Schrank, T.P.,Bolen, D.W.,Hilser, V.J.
Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins.
Proc.Natl.Acad.Sci.USA, 106:16984-16989, 2009
PubMed: 19805185 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0906510106
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2401004.0%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution