8FDT
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![BU of 8fdt by Molmil](/molmil-images/mine/8fdt) | Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, ... | Authors: | Ton, W, Wang, Y, Chai, P. | Deposit date: | 2022-12-04 | Release date: | 2023-06-21 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport. Nat.Struct.Mol.Biol., 30, 2023
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8G1U
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![BU of 8g1u by Molmil](/molmil-images/mine/8g1u) | Structure of the methylosome-Lsm10/11 complex | Descriptor: | ADENOSINE, Methylosome protein 50, Methylosome subunit pICln, ... | Authors: | Lin, M, Paige, A, Tong, L. | Deposit date: | 2023-02-03 | Release date: | 2023-08-23 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome. Rna, 29, 2023
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7XP6
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![BU of 7xp6 by Molmil](/molmil-images/mine/7xp6) | Cryo-EM structure of a class T GPCR in active state | Descriptor: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | Deposit date: | 2022-05-03 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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7XP4
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![BU of 7xp4 by Molmil](/molmil-images/mine/7xp4) | Cryo-EM structure of a class T GPCR in apo state | Descriptor: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | Deposit date: | 2022-05-03 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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7XP5
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![BU of 7xp5 by Molmil](/molmil-images/mine/7xp5) | Cryo-EM structure of a class T GPCR in ligand-free state | Descriptor: | Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | Deposit date: | 2022-05-03 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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7BO7
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![BU of 7bo7 by Molmil](/molmil-images/mine/7bo7) | CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437 | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-[(4~{a}~{S},7~{a}~{S})-4-azanyl-1,4,4~{a},7~{a}-tetrahydropyrrolo[2,3-d]pyrimidin-7-yl]-5-(quinolin-7-yloxymethyl)oxolane-3,4-diol, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Brown, D, Robinson, C, Carr, K.H, Pande, V. | Deposit date: | 2021-01-24 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437 To Be Published
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7Y5K
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![BU of 7y5k by Molmil](/molmil-images/mine/7y5k) | Crystal structure of human CAF-1 core complex in spacegroup C2221 | Descriptor: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ... | Authors: | Liu, C.P, Wang, M.Z, Xu, R.M. | Deposit date: | 2022-06-17 | Release date: | 2023-08-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.48 Å) | Cite: | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
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7Y5O
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![BU of 7y5o by Molmil](/molmil-images/mine/7y5o) | Crystal structure of human CAF-1 core complex in spacegroup P21 | Descriptor: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ... | Authors: | Liu, C.P, Wang, M.Z, Xu, R.M. | Deposit date: | 2022-06-17 | Release date: | 2023-08-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.57 Å) | Cite: | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
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7Y5L
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![BU of 7y5l by Molmil](/molmil-images/mine/7y5l) | Crystal structure of human CAF-1 core complex in spacegroup C2 | Descriptor: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ... | Authors: | Liu, C.P, Wang, M.Z, Xu, R.M. | Deposit date: | 2022-06-17 | Release date: | 2023-08-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.42 Å) | Cite: | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
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7EGG
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![BU of 7egg by Molmil](/molmil-images/mine/7egg) | TFIID lobe B subcomplex | Descriptor: | Transcription initiation factor TFIID subunit 10, Transcription initiation factor TFIID subunit 12, Transcription initiation factor TFIID subunit 4, ... | Authors: | Chen, X, Wu, Z, Li, J, Zhao, D, Xu, Y. | Deposit date: | 2021-03-24 | Release date: | 2021-05-05 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EMF
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![BU of 7emf by Molmil](/molmil-images/mine/7emf) | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | Descriptor: | Isoform 2 of Mediator of RNA polymerase II transcription subunit 16, Isoform 2 of Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 1, ... | Authors: | Yin, X, Li, J, Wu, Z, Liu, W, Xu, Y. | Deposit date: | 2021-04-13 | Release date: | 2021-05-05 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of the human Mediator and Mediator-bound preinitiation complex. Science, 372, 2021
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7ZGR
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![BU of 7zgr by Molmil](/molmil-images/mine/7zgr) | |
7ZGP
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![BU of 7zgp by Molmil](/molmil-images/mine/7zgp) | |
7ZGQ
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![BU of 7zgq by Molmil](/molmil-images/mine/7zgq) | |
7ENJ
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![BU of 7enj by Molmil](/molmil-images/mine/7enj) | Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B) | Descriptor: | Isoform 2 of Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ... | Authors: | Yin, X, Li, J, Wu, Z, Liu, W, Xu, Y. | Deposit date: | 2021-04-17 | Release date: | 2021-05-19 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structures of the human Mediator and Mediator-bound preinitiation complex. Science, 372, 2021
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7ZU0
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![BU of 7zu0 by Molmil](/molmil-images/mine/7zu0) | HOPS tethering complex from yeast | Descriptor: | E3 ubiquitin-protein ligase PEP5, Vacuolar membrane protein PEP3, Vacuolar morphogenesis protein 6, ... | Authors: | Shvarev, D, Schoppe, J, Koenig, C, Perz, A, Fuellbrunn, N, Kiontke, S, Langemeyer, L, Januliene, D, Schnelle, K, Kuemmel, D, Froehlich, F, Moeller, A, Ungermann, C. | Deposit date: | 2022-05-11 | Release date: | 2022-09-28 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery. Elife, 11, 2022
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7ZV2
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![BU of 7zv2 by Molmil](/molmil-images/mine/7zv2) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... | Authors: | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | Deposit date: | 2022-05-13 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZVL
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![BU of 7zvl by Molmil](/molmil-images/mine/7zvl) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, GLYCEROL, ... | Authors: | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | Deposit date: | 2022-05-16 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZUU
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![BU of 7zuu by Molmil](/molmil-images/mine/7zuu) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... | Authors: | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | Deposit date: | 2022-05-13 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZUQ
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![BU of 7zuq by Molmil](/molmil-images/mine/7zuq) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... | Authors: | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | Deposit date: | 2022-05-13 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZUY
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![BU of 7zuy by Molmil](/molmil-images/mine/7zuy) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... | Authors: | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | Deposit date: | 2022-05-13 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZUP
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![BU of 7zup by Molmil](/molmil-images/mine/7zup) | Human PRMT5:MEP50 structure with Fragment (Example 18) and MTA Bound | Descriptor: | 3-ethylimidazo[4,5-b]pyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, ... | Authors: | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | Deposit date: | 2022-05-12 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZVU
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![BU of 7zvu by Molmil](/molmil-images/mine/7zvu) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... | Authors: | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | Deposit date: | 2022-05-17 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7BYF
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![BU of 7byf by Molmil](/molmil-images/mine/7byf) | The crystal structure of mouse ORF10-Rae1-Nup98 complex | Descriptor: | 10 protein, MERCURY (II) ION, Peptidase S59 domain-containing protein, ... | Authors: | Gao, P, Feng, H. | Deposit date: | 2020-04-22 | Release date: | 2021-03-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10. Proc.Natl.Acad.Sci.USA, 117, 2020
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7Z8J
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![BU of 7z8j by Molmil](/molmil-images/mine/7z8j) | Cytoplasmic dynein (A2) bound to BICDR1 | Descriptor: | BICD family-like cargo adapter 1, Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, ... | Authors: | Chaaban, S, Carter, A.P. | Deposit date: | 2022-03-17 | Release date: | 2022-07-27 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Structure of dynein-dynactin on microtubules shows tandem adaptor binding. Nature, 610, 2022
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