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8FDT
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BU of 8fdt by Molmil
Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, ...
Authors:Ton, W, Wang, Y, Chai, P.
Deposit date:2022-12-04
Release date:2023-06-21
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
Nat.Struct.Mol.Biol., 30, 2023
8G1U
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BU of 8g1u by Molmil
Structure of the methylosome-Lsm10/11 complex
Descriptor: ADENOSINE, Methylosome protein 50, Methylosome subunit pICln, ...
Authors:Lin, M, Paige, A, Tong, L.
Deposit date:2023-02-03
Release date:2023-08-23
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome.
Rna, 29, 2023
7XP6
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BU of 7xp6 by Molmil
Cryo-EM structure of a class T GPCR in active state
Descriptor: Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J.
Deposit date:2022-05-03
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structural basis for strychnine activation of human bitter taste receptor TAS2R46.
Science, 377, 2022
7XP4
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BU of 7xp4 by Molmil
Cryo-EM structure of a class T GPCR in apo state
Descriptor: Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J.
Deposit date:2022-05-03
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structural basis for strychnine activation of human bitter taste receptor TAS2R46.
Science, 377, 2022
7XP5
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BU of 7xp5 by Molmil
Cryo-EM structure of a class T GPCR in ligand-free state
Descriptor: Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J.
Deposit date:2022-05-03
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structural basis for strychnine activation of human bitter taste receptor TAS2R46.
Science, 377, 2022
7BO7
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BU of 7bo7 by Molmil
CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437
Descriptor: (2~{R},3~{R},4~{S},5~{R})-2-[(4~{a}~{S},7~{a}~{S})-4-azanyl-1,4,4~{a},7~{a}-tetrahydropyrrolo[2,3-d]pyrimidin-7-yl]-5-(quinolin-7-yloxymethyl)oxolane-3,4-diol, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Brown, D, Robinson, C, Carr, K.H, Pande, V.
Deposit date:2021-01-24
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437
To Be Published
7Y5K
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BU of 7y5k by Molmil
Crystal structure of human CAF-1 core complex in spacegroup C2221
Descriptor: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ...
Authors:Liu, C.P, Wang, M.Z, Xu, R.M.
Deposit date:2022-06-17
Release date:2023-08-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
7Y5O
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BU of 7y5o by Molmil
Crystal structure of human CAF-1 core complex in spacegroup P21
Descriptor: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ...
Authors:Liu, C.P, Wang, M.Z, Xu, R.M.
Deposit date:2022-06-17
Release date:2023-08-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.57 Å)
Cite:Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
7Y5L
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BU of 7y5l by Molmil
Crystal structure of human CAF-1 core complex in spacegroup C2
Descriptor: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ...
Authors:Liu, C.P, Wang, M.Z, Xu, R.M.
Deposit date:2022-06-17
Release date:2023-08-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
7EGG
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BU of 7egg by Molmil
TFIID lobe B subcomplex
Descriptor: Transcription initiation factor TFIID subunit 10, Transcription initiation factor TFIID subunit 12, Transcription initiation factor TFIID subunit 4, ...
Authors:Chen, X, Wu, Z, Li, J, Zhao, D, Xu, Y.
Deposit date:2021-03-24
Release date:2021-05-05
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
7EMF
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BU of 7emf by Molmil
Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation
Descriptor: Isoform 2 of Mediator of RNA polymerase II transcription subunit 16, Isoform 2 of Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 1, ...
Authors:Yin, X, Li, J, Wu, Z, Liu, W, Xu, Y.
Deposit date:2021-04-13
Release date:2021-05-05
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of the human Mediator and Mediator-bound preinitiation complex.
Science, 372, 2021
7ZGR
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BU of 7zgr by Molmil
Polymerase module of yeast CPF in complex with Mpe1, the yPIM of Cft2 and the pre-cleaved CYC1 RNA
Descriptor: Cleavage factor two protein 2, MPE1 isoform 1, Polyadenylation factor subunit 2, ...
Authors:Rodriguez-Molina, J.B, Passmore, L.A.
Deposit date:2022-04-04
Release date:2022-05-25
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Mpe1 senses the binding of pre-mRNA and controls 3' end processing by CPF.
Mol.Cell, 82, 2022
7ZGP
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BU of 7zgp by Molmil
Polymerase module of CPF in complex with Mpe1 and a pre-cleaved CYC1 RNA
Descriptor: MPE1 isoform 1, Polyadenylation factor subunit 2, Protein CFT1, ...
Authors:Rodriguez-Molina, J.B, Passmore, L.A.
Deposit date:2022-04-04
Release date:2022-05-25
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Mpe1 senses the binding of pre-mRNA and controls 3' end processing by CPF.
Mol.Cell, 82, 2022
7ZGQ
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BU of 7zgq by Molmil
Polymerase module of yeast CPF in complex with the yPIM of Cft2
Descriptor: Cleavage factor two protein 2, Polyadenylation factor subunit 2, Protein CFT1, ...
Authors:Rodriguez-Molina, J.B, Passmore, L.A.
Deposit date:2022-04-04
Release date:2022-05-25
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Mpe1 senses the binding of pre-mRNA and controls 3' end processing by CPF.
Mol.Cell, 82, 2022
7ENJ
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BU of 7enj by Molmil
Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B)
Descriptor: Isoform 2 of Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ...
Authors:Yin, X, Li, J, Wu, Z, Liu, W, Xu, Y.
Deposit date:2021-04-17
Release date:2021-05-19
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structures of the human Mediator and Mediator-bound preinitiation complex.
Science, 372, 2021
7ZU0
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BU of 7zu0 by Molmil
HOPS tethering complex from yeast
Descriptor: E3 ubiquitin-protein ligase PEP5, Vacuolar membrane protein PEP3, Vacuolar morphogenesis protein 6, ...
Authors:Shvarev, D, Schoppe, J, Koenig, C, Perz, A, Fuellbrunn, N, Kiontke, S, Langemeyer, L, Januliene, D, Schnelle, K, Kuemmel, D, Froehlich, F, Moeller, A, Ungermann, C.
Deposit date:2022-05-11
Release date:2022-09-28
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.
Elife, 11, 2022
7ZV2
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BU of 7zv2 by Molmil
HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ...
Authors:Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J.
Deposit date:2022-05-13
Release date:2022-10-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
7ZVL
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BU of 7zvl by Molmil
HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, GLYCEROL, ...
Authors:Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J.
Deposit date:2022-05-16
Release date:2022-10-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
7ZUU
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BU of 7zuu by Molmil
HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ...
Authors:Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J.
Deposit date:2022-05-13
Release date:2022-10-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
7ZUQ
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BU of 7zuq by Molmil
HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ...
Authors:Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J.
Deposit date:2022-05-13
Release date:2022-10-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
7ZUY
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BU of 7zuy by Molmil
HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ...
Authors:Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J.
Deposit date:2022-05-13
Release date:2022-10-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
7ZUP
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BU of 7zup by Molmil
Human PRMT5:MEP50 structure with Fragment (Example 18) and MTA Bound
Descriptor: 3-ethylimidazo[4,5-b]pyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, ...
Authors:Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J.
Deposit date:2022-05-12
Release date:2022-10-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
7ZVU
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BU of 7zvu by Molmil
HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ...
Authors:Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J.
Deposit date:2022-05-17
Release date:2022-10-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
7BYF
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BU of 7byf by Molmil
The crystal structure of mouse ORF10-Rae1-Nup98 complex
Descriptor: 10 protein, MERCURY (II) ION, Peptidase S59 domain-containing protein, ...
Authors:Gao, P, Feng, H.
Deposit date:2020-04-22
Release date:2021-03-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10.
Proc.Natl.Acad.Sci.USA, 117, 2020
7Z8J
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BU of 7z8j by Molmil
Cytoplasmic dynein (A2) bound to BICDR1
Descriptor: BICD family-like cargo adapter 1, Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, ...
Authors:Chaaban, S, Carter, A.P.
Deposit date:2022-03-17
Release date:2022-07-27
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022

221716

數據於2024-06-26公開中

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