8F76
 
 | | Human olfactory receptor OR51E2 bound to propionate in complex with miniGs399 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Billesboelle, C.B, Manglik, A. | | Deposit date: | 2022-11-18 | | Release date: | 2023-03-22 | | Last modified: | 2023-04-05 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of odorant recognition by a human odorant receptor.
Nature, 615, 2023
|
|
8F5P
 | | Structure of Leishmania tarentolae IFT-A (state 2) | | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 122B, putative, ... | | Authors: | Zhou, H, Brown, A. | | Deposit date: | 2022-11-14 | | Release date: | 2022-12-21 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Mechanism of IFT-A polymerization into trains for ciliary transport.
Cell, 185, 2022
|
|
8F5O
 | | Structure of Leishmania tarentolae IFT-A (state 1) | | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 122B, putative, ... | | Authors: | Zhou, H, Brown, A. | | Deposit date: | 2022-11-14 | | Release date: | 2022-12-21 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Mechanism of IFT-A polymerization into trains for ciliary transport.
Cell, 185, 2022
|
|
8EG0
 | |
8FH3
 | | Human IFT-A complex structures provide molecular insights into ciliary transport | | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, Tubby-related protein 3, ... | | Authors: | Jiang, M, Palicharla, V.R, Miller, D, Hwang, S.H, Zhu, H, Hixson, P, Mukhopadhyay, S, Sun, J. | | Deposit date: | 2022-12-13 | | Release date: | 2023-02-22 | | Last modified: | 2023-04-12 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Human IFT-A complex structures provide molecular insights into ciliary transport.
Cell Res., 33, 2023
|
|
8FGW
 | | Human IFT-A complex structures provide molecular insights into ciliary transport | | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, Intraflagellar transport protein 43 homolog, ... | | Authors: | Jiang, M, Palicharla, V.R, Miller, D, Hwang, S.H, Zhu, H, Hixson, P, Mukhopadhyay, S, Sun, J. | | Deposit date: | 2022-12-12 | | Release date: | 2023-02-22 | | Last modified: | 2023-04-12 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Human IFT-A complex structures provide molecular insights into ciliary transport.
Cell Res., 33, 2023
|
|
7STY
 | | Crystal structure of human CORO1C | | Descriptor: | Coronin-1C | | Authors: | Zeng, H, Dong, A, Hutchinson, A, Seitova, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2021-11-15 | | Release date: | 2021-12-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of human CORO1C
To Be Published
|
|
7TDZ
 | |
7TD5
 | | Structure of human PRC2-EZH1 containing phosphorylated SUZ12 | | Descriptor: | Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, Polycomb protein SUZ12, ... | | Authors: | Gong, L, Jiao, L, Liu, X. | | Deposit date: | 2021-12-30 | | Release date: | 2022-11-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.994 Å) | | Cite: | CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site.
Nat Commun, 13, 2022
|
|
7TRC
 | | Human telomerase H/ACA RNP at 3.3 Angstrom | | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | | Authors: | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | | Deposit date: | 2022-01-28 | | Release date: | 2022-04-20 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of active human telomerase with telomere shelterin protein TPP1.
Nature, 604, 2022
|
|
7U20
 | | Crystal structure of human METTL1 and WDR4 complex | | Descriptor: | SULFATE ION, tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 | | Authors: | Li, J, Nowak, R.P, Fischer, E.S, Gregory, R. | | Deposit date: | 2022-02-22 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4.
Nature, 613, 2023
|
|
7TZO
 | | The apo structure of human mTORC2 complex | | Descriptor: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | | Authors: | Yu, Z, Chen, J, Pearce, D. | | Deposit date: | 2022-02-16 | | Release date: | 2023-01-11 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
J.Biol.Chem., 298, 2022
|
|
7T1Y
 | | Structure of the Fbw7-Skp1-MycCdegron complex | | Descriptor: | F-box/WD repeat-containing protein 7, Myc proto-oncogene protein C terminal degron, S-phase kinase-associated protein 1, ... | | Authors: | Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N. | | Deposit date: | 2021-12-02 | | Release date: | 2022-02-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Sci Adv, 8, 2022
|
|
7T1Z
 | | Structure of the Fbw7-Skp1-MycNdegron complex | | Descriptor: | F-box/WD repeat-containing protein 7, Myc proto-oncogene N terminal degron, S-phase kinase-associated protein 1, ... | | Authors: | Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N. | | Deposit date: | 2021-12-02 | | Release date: | 2022-02-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Sci Adv, 8, 2022
|
|
7UYF
 | | Human PRMT5:MEP50 structure with Fragment 4 and MTA Bound | | Descriptor: | 4-methyl-1,5-naphthyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... | | Authors: | Gunn, R.J, Lawson, J.D, Smith, C.R. | | Deposit date: | 2022-05-06 | | Release date: | 2022-10-05 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.82 Å) | | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
|
|
7UY1
 | | HUMAN PRMT5:MEP50 COMPLEX WITH MTA and Fragment 5 Bound | | Descriptor: | 1,2-ETHANEDIOL, 3-methyl-1,5-naphthyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... | | Authors: | Gunn, R.J. | | Deposit date: | 2022-05-06 | | Release date: | 2022-10-05 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.66 Å) | | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
Rsc Med Chem, 13, 2022
|
|
7UHY
 | | Human GATOR2 complex | | Descriptor: | GATOR complex protein MIOS, GATOR complex protein WDR24, GATOR complex protein WDR59, ... | | Authors: | Rogala, K.B, Valenstein, M.L, Lalgudi, P.V. | | Deposit date: | 2022-03-27 | | Release date: | 2022-07-20 | | Last modified: | 2022-08-03 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Structure of the nutrient-sensing hub GATOR2.
Nature, 607, 2022
|
|
7V2W
 | | protomer structure from the dimer of yeast THO complex | | Descriptor: | Protein TEX1, THO complex subunit 2, THO complex subunit HPR1, ... | | Authors: | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | | Deposit date: | 2021-08-10 | | Release date: | 2022-07-27 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex.
Sci Bull (Beijing), 66, 2021
|
|
7UWF
 | | Human Rix1 sub-complex scaffold | | Descriptor: | Modulator of non-genomic activity of estrogen receptor, WD repeat-containing protein 18 | | Authors: | Gordon, J, Stanley, R.E. | | Deposit date: | 2022-05-03 | | Release date: | 2022-11-02 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Cryo-EM reveals the architecture of the PELP1-WDR18 molecular scaffold.
Nat Commun, 13, 2022
|
|
7UOH
 | | PRMT5/MEP50 crystal structure with MTA and an achiral, class 1, non-atropisomeric inhibitor bound | | Descriptor: | (2M)-2-[(4M)-4-{4-(aminomethyl)-1-oxo-8-[(2R)-oxolan-2-yl]-1,2-dihydrophthalazin-6-yl}-1-methyl-1H-pyrazol-5-yl]-1-benzothiophene-3-carbonitrile, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... | | Authors: | Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Kulyk, S, Smith, C.R, Marx, M.A. | | Deposit date: | 2022-04-12 | | Release date: | 2022-08-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors.
Bioorg.Med.Chem., 71, 2022
|
|
7U30
 | | PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1 | | Descriptor: | (9R,10R,11S,12R,13R,14R)-4-amino-9-(3,4-difluorophenyl)-6,7,8,9,10,11,12,13-octahydro-10,13-epoxy[1,3]diazecino[1,2-e]purine-11,12-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | | Authors: | Palte, R.L. | | Deposit date: | 2022-02-25 | | Release date: | 2022-06-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity.
Bioorg.Med.Chem., 66, 2022
|
|
8PQY
 | | Cytoplasmic dynein-1 motor domain bound to LIS1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | | Authors: | Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-27 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Science, 383, 2024
|
|
8PR2
 | | Cytoplasmic dynein-1 heavy chain bound to JIP3-LZI | | Descriptor: | C-Jun-amino-terminal kinase-interacting protein 3, Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, ... | | Authors: | Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-27 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Science, 383, 2024
|
|
8PR0
 | | Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower | | Descriptor: | Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, Cytoplasmic dynein 1 light intermediate chain 2, ... | | Authors: | Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-27 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (9.4 Å) | | Cite: | Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Science, 383, 2024
|
|
8PR1
 | | Cytoplasmic dynein-B heavy chain bound to IC-LC tower | | Descriptor: | Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, Cytoplasmic dynein 1 light intermediate chain 2, ... | | Authors: | Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-27 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (8.2 Å) | | Cite: | Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Science, 383, 2024
|
|
