7TD5

Structure of human PRC2-EZH1 containing phosphorylated SUZ12

Summary for 7TD5

• Entry DOI: 10.2210/pdb7td5/pdb
• Descriptor: Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, Polycomb protein SUZ12, ... (7 entities in total)
• Functional Keywords: transcription regulatory complex, histone modification, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 304787.73

Authors

Gong, L.,Jiao, L.,Liu, X. (deposition date: 2021-12-30, release date: 2022-11-16, Last modification date: 2023-10-18)

• Primary citation: Gong, L.,Liu, X.,Jiao, L.,Yang, X.,Lemoff, A.,Liu, X.; CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site.; Nat Commun, 13:6781-6781, 2022; PubMed: 36351927; DOI: 10.1038/s41467-022-34431-1

Experimental method

X-RAY DIFFRACTION (2.994 Å)