7TD5

Structure of human PRC2-EZH1 containing phosphorylated SUZ12

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F	Histone-lysine N-methyltransferase EZH1	polymer	747	85394.1	2	UniProt (Q92800) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) In PDB	Homo sapiens (human)	ENX-2,Enhancer of zeste homolog 1
2	B, G	Polycomb protein EED	polymer	373	43170.1	2	UniProt (O75530) Pfam (PF00400) In PDB	Homo sapiens (human)	hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1
3	C, H	Polycomb protein SUZ12	polymer	179	20841.5	2	UniProt (Q15022) Pfam (PF09733) In PDB	Homo sapiens (human)	Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog
4	D, I	THR-LYS-ALA-ALA-ARG-MET-SER-ALA-PRO-SER	polymer	10	1021.2	2	UniProt (by SIFTS) (P68431) In PDB	Homo sapiens
5	E, J	THR-LYS-ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA	polymer	10	1045.3	2	UniProt (by SIFTS) (P68431) In PDB	Homo sapiens
6	F, A	ZINC ION	non-polymer		65.4	16	Chemie (ZN)
7	F, A	S-ADENOSYLMETHIONINE	non-polymer		398.4	2	Chemie (SAM)

Sequence modifications

B, G: 77 - 441 (UniProt: O75530)

PDB	External Database	Details
Ser 69	-	expression tag
Trp 70	-	expression tag
Ser 71	-	expression tag
His 72	-	expression tag
Pro 73	-	expression tag
Gln 74	-	expression tag
Phe 75	-	expression tag
Glu 76	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	302944.3
Non-Polymers*	Number of molecules	18
	Total formula weight	1843.4
All*	Total formula weight	304787.7

*Water molecules are not included.