7TD5
Structure of human PRC2-EZH1 containing phosphorylated SUZ12
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F (A, F) | Histone-lysine N-methyltransferase EZH1 | polymer | 747 | 85394.1 | 2 | UniProt (Q92800) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) | Homo sapiens (human) | ENX-2,Enhancer of zeste homolog 1 |
| 2 | B, G (B, G) | Polycomb protein EED | polymer | 373 | 43170.1 | 2 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 3 | C, H (C, H) | Polycomb protein SUZ12 | polymer | 179 | 20841.5 | 2 | UniProt (Q15022) Pfam (PF09733) | Homo sapiens (human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 4 | D, I (D, I) | THR-LYS-ALA-ALA-ARG-MET-SER-ALA-PRO-SER | polymer | 10 | 1021.2 | 2 | UniProt (by SIFTS) (P68431) | Homo sapiens | |
| 5 | E, J (E, J) | THR-LYS-ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA | polymer | 10 | 1045.3 | 2 | UniProt (by SIFTS) (P68431) | Homo sapiens | |
| 6 | AA, K, L, M, N... (F, A) | ZINC ION | non-polymer | 65.4 | 16 | Chemie (ZN) | |||
| 7 | BA, S (F, A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (58766358) PubChem (73897310) PubChem (9865603) PubChem (87224684) PubChem (12312798) PubChem (131697735) PubChem (145712080) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) |
Sequence modifications
B, G: 77 - 441 (UniProt: O75530)
| PDB | External Database | Details |
|---|---|---|
| Ser 69 | - | expression tag |
| Trp 70 | - | expression tag |
| Ser 71 | - | expression tag |
| His 72 | - | expression tag |
| Pro 73 | - | expression tag |
| Gln 74 | - | expression tag |
| Phe 75 | - | expression tag |
| Glu 76 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 302944.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1843.4 | |
| All* | Total formula weight | 304787.7 |
