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7TD5

Structure of human PRC2-EZH1 containing phosphorylated SUZ12

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000781cellular_componentchromosome, telomeric region
A0000792cellular_componentheterochromatin
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003714molecular_functiontranscription corepressor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0008168molecular_functionmethyltransferase activity
A0009653biological_processanatomical structure morphogenesis
A0021766biological_processhippocampus development
A0031491molecular_functionnucleosome binding
A0031507biological_processheterochromatin formation
A0031509biological_processsubtelomeric heterochromatin formation
A0032259biological_processmethylation
A0035098cellular_componentESC/E(Z) complex
A0042054molecular_functionhistone methyltransferase activity
A0042393molecular_functionhistone binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046976molecular_functionhistone H3K27 methyltransferase activity
A0140693molecular_functionmolecular condensate scaffold activity
A0140951molecular_functionhistone H3K27 trimethyltransferase activity
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000781cellular_componentchromosome, telomeric region
F0000792cellular_componentheterochromatin
F0003677molecular_functionDNA binding
F0003682molecular_functionchromatin binding
F0003714molecular_functiontranscription corepressor activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0006325biological_processchromatin organization
F0006338biological_processchromatin remodeling
F0008168molecular_functionmethyltransferase activity
F0009653biological_processanatomical structure morphogenesis
F0021766biological_processhippocampus development
F0031491molecular_functionnucleosome binding
F0031507biological_processheterochromatin formation
F0031509biological_processsubtelomeric heterochromatin formation
F0032259biological_processmethylation
F0035098cellular_componentESC/E(Z) complex
F0042054molecular_functionhistone methyltransferase activity
F0042393molecular_functionhistone binding
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0046976molecular_functionhistone H3K27 methyltransferase activity
F0140693molecular_functionmolecular condensate scaffold activity
F0140951molecular_functionhistone H3K27 trimethyltransferase activity
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI
ChainResidueDetails
BLEU206-ILE220

site_idPS00729
Number of Residues9
DetailsAP_NUCLEASE_F2_1 AP endonucleases family 2 signature 1. HGtYFNNFC
ChainResidueDetails
AHIS446-CYS454

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708
ChainResidueDetails
ELYS23
JLYS23
BLYS284
GLYS197
GLYS268
GLYS284

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Citrulline => ECO:0000269|PubMed:16567635
ChainResidueDetails
EARG26
JARG26

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708
ChainResidueDetails
EM3L27
JM3L27

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588
ChainResidueDetails
ESER28
JSER28

222926

PDB entries from 2024-07-24

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