7TD5
Structure of human PRC2-EZH1 containing phosphorylated SUZ12
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000781 | cellular_component | chromosome, telomeric region |
| A | 0000792 | cellular_component | heterochromatin |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0009653 | biological_process | anatomical structure morphogenesis |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0021766 | biological_process | hippocampus development |
| A | 0031491 | molecular_function | nucleosome binding |
| A | 0031507 | biological_process | heterochromatin formation |
| A | 0031509 | biological_process | subtelomeric heterochromatin formation |
| A | 0035098 | cellular_component | ESC/E(Z) complex |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0042393 | molecular_function | histone binding |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0046976 | molecular_function | histone H3K27 methyltransferase activity |
| A | 0140693 | molecular_function | molecular condensate scaffold activity |
| A | 0140951 | molecular_function | histone H3K27 trimethyltransferase activity |
| F | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| F | 0000781 | cellular_component | chromosome, telomeric region |
| F | 0000792 | cellular_component | heterochromatin |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003682 | molecular_function | chromatin binding |
| F | 0003714 | molecular_function | transcription corepressor activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005654 | cellular_component | nucleoplasm |
| F | 0006338 | biological_process | chromatin remodeling |
| F | 0009653 | biological_process | anatomical structure morphogenesis |
| F | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| F | 0021766 | biological_process | hippocampus development |
| F | 0031491 | molecular_function | nucleosome binding |
| F | 0031507 | biological_process | heterochromatin formation |
| F | 0031509 | biological_process | subtelomeric heterochromatin formation |
| F | 0035098 | cellular_component | ESC/E(Z) complex |
| F | 0042054 | molecular_function | histone methyltransferase activity |
| F | 0042393 | molecular_function | histone binding |
| F | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| F | 0046976 | molecular_function | histone H3K27 methyltransferase activity |
| F | 0140693 | molecular_function | molecular condensate scaffold activity |
| F | 0140951 | molecular_function | histone H3K27 trimethyltransferase activity |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 230 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 86 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 86 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 74 |
| Details | Repeat: {"description":"WD 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 360 |
| Details | Region: {"description":"Interaction with EZH2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 448 |
| Details | Region: {"description":"Required for interaction with the matrix protein MA of HIV-1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Citrulline","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5","evidences":[{"source":"PubMed","id":"10464286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11856369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15684425","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"27595565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29053958","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
