8EG0

CryoEM structure of human METTL1-WDR4 in complex with Lys-tRNA and SAH

Summary for 8EG0

• Entry DOI: 10.2210/pdb8eg0/pdb
• Related: 8D9K 8D9L
• EMDB information: 27264 27265 28108
• Descriptor: tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4, tRNA (guanine-N(7)-)-methyltransferase, RNA (65-MER), ... (4 entities in total)
• Functional Keywords: cancer protein, methyl transferase, transferase, transferase-rna complex, transferase/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 100186.15

Authors

Ruiz-Arroyo, V.M.,Nam, Y. (deposition date: 2022-09-10, release date: 2023-01-11, Last modification date: 2024-06-19)

• Primary citation: Ruiz-Arroyo, V.M.,Raj, R.,Babu, K.,Onolbaatar, O.,Roberts, P.H.,Nam, Y.; Structures and mechanisms of tRNA methylation by METTL1-WDR4.; Nature, 613:383-390, 2023; PubMed: 36599982; DOI: 10.1038/s41586-022-05565-5

Experimental method

ELECTRON MICROSCOPY (3.53 Å)