5HYE
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![BU of 5hye by Molmil](/molmil-images/mine/5hye) | Glycosylated Knob-Knob Fc fragment (P212121) | Descriptor: | Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Kuglstatter, A, Stihle, M, Benz, J. | Deposit date: | 2016-02-01 | Release date: | 2017-02-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products. Protein Eng. Des. Sel., 30, 2017
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5HY9
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![BU of 5hy9 by Molmil](/molmil-images/mine/5hy9) | Glycosylated, disulfide-linked Knob-into-Hole Fc fragment | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Kuglstatter, A, Stihle, M, Benz, J. | Deposit date: | 2016-02-01 | Release date: | 2017-02-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products. Protein Eng. Des. Sel., 30, 2017
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6ADB
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![BU of 6adb by Molmil](/molmil-images/mine/6adb) | Crystal structure of the E148N mutant CLC-ec1 in 20mM bromide | Descriptor: | BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment, ... | Authors: | Lim, H.-H, Park, K. | Deposit date: | 2018-07-31 | Release date: | 2019-08-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.692 Å) | Cite: | Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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6AD7
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![BU of 6ad7 by Molmil](/molmil-images/mine/6ad7) | Crystal structure of the E148D mutant CLC-ec1 in 20 mM bromide | Descriptor: | BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | Authors: | Lim, H.-H, Park, K. | Deposit date: | 2018-07-31 | Release date: | 2019-08-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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6ADC
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![BU of 6adc by Molmil](/molmil-images/mine/6adc) | |
6ADA
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![BU of 6ada by Molmil](/molmil-images/mine/6ada) | Crystal structure of the E148D mutant CLC-ec1 in 200mM bromide | Descriptor: | BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment, ... | Authors: | Lim, H.-H, Park, K. | Deposit date: | 2018-07-31 | Release date: | 2019-08-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.153 Å) | Cite: | Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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2Y7S
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![BU of 2y7s by Molmil](/molmil-images/mine/2y7s) | |
6AVN
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6AWQ
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![BU of 6awq by Molmil](/molmil-images/mine/6awq) | Anomalous chloride signal reveals the position of sertraline complexed with the serotonin transporter at the central site | Descriptor: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody FAB heavy chain, ... | Authors: | Coleman, J.A, Gouaux, E. | Deposit date: | 2017-09-06 | Release date: | 2017-10-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.046 Å) | Cite: | Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Nat. Struct. Mol. Biol., 25, 2018
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6AWN
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![BU of 6awn by Molmil](/molmil-images/mine/6awn) | |
6AWP
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6AWO
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![BU of 6awo by Molmil](/molmil-images/mine/6awo) | X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site | Descriptor: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody FAB heavy chain, ... | Authors: | Coleman, J.A, Gouaux, E. | Deposit date: | 2017-09-06 | Release date: | 2017-10-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.534 Å) | Cite: | Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Nat. Struct. Mol. Biol., 25, 2018
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6TGG
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![BU of 6tgg by Molmil](/molmil-images/mine/6tgg) | scFv-1SM3 in complex with glycopeptide containing an sp2-imino sugar | Descriptor: | 1,2-ETHANEDIOL, Mucin-1, ScFv_SM3, ... | Authors: | Bermejo, I.A, Navo, C.D, Castro-Lopez, J, Samchez-Fernandez, E.M, Guerreiro, A, Avenoza, A, Busto, J.H, Garcia-Martin, F, Nishimura, S.I, Garcia-Fernandez, J.M, Ortiz-Mellet, C, Bernardes, G.J.L, Hurtado-Guerrero, R, Peregrina, J.M, Corzana, F. | Deposit date: | 2019-11-15 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp 2 -iminosugar fragment. Chem Sci, 11, 2020
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6CF2
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![BU of 6cf2 by Molmil](/molmil-images/mine/6cf2) | Crystal structure of HIV-1 Rev (residues 1-93)-RNA aptamer complex | Descriptor: | Anti-Rev Antibody, heavy chain, light chain, ... | Authors: | Eren, E, Dearborn, A.D, Wingfield, P.T. | Deposit date: | 2018-02-13 | Release date: | 2018-07-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of an RNA Aptamer that Can Inhibit HIV-1 by Blocking Rev-Cognate RNA (RRE) Binding and Rev-Rev Association. Structure, 26, 2018
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3C08
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![BU of 3c08 by Molmil](/molmil-images/mine/3c08) | |
7YD3
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![BU of 7yd3 by Molmil](/molmil-images/mine/7yd3) | Single-chain variable fragment of app 3D1 antibody | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Yan, L, Yang, G. | Deposit date: | 2022-07-03 | Release date: | 2023-07-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Cross-reactive epitopes between HIV and Coronavirus revealed by 3D1 To Be Published
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7RGA
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![BU of 7rga by Molmil](/molmil-images/mine/7rga) | Crystal structure of nanoCLAMP3:VHH in complex with MTX | Descriptor: | METHOTREXATE, SODIUM ION, nano CLostridial Antibody Mimetic Protein 3 VHH | Authors: | Guo, Z, Alexandrov, K. | Deposit date: | 2021-07-14 | Release date: | 2022-05-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices. Nat Commun, 12, 2021
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7S6D
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![BU of 7s6d by Molmil](/molmil-images/mine/7s6d) | CryoEM structure of modular PKS holo-Lsd14 bound to antibody fragment 1B2, composite structure | Descriptor: | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, ... | Authors: | Bagde, S.R, Kim, C.-Y, Fromme, J.C. | Deposit date: | 2021-09-13 | Release date: | 2021-11-03 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374, 2021
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8IY9
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![BU of 8iy9 by Molmil](/molmil-images/mine/8iy9) | Structure of Niacin-GPR109A-G protein complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | Authors: | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | Deposit date: | 2023-04-04 | Release date: | 2024-03-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. Nat Commun, 15, 2024
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8IYH
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![BU of 8iyh by Molmil](/molmil-images/mine/8iyh) | Structure of MK6892-GPR109A-G-protein complex | Descriptor: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | Deposit date: | 2023-04-04 | Release date: | 2024-03-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. Nat Commun, 15, 2024
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7U0Y
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7LWD
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![BU of 7lwd by Molmil](/molmil-images/mine/7lwd) | Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, ... | Authors: | Yang, D, Kalenderoglou, I.E, Gouaux, E, Coleman, J.A, Loland, C.J. | Deposit date: | 2021-03-01 | Release date: | 2021-08-11 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter. Nat Commun, 12, 2021
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8WDT
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![BU of 8wdt by Molmil](/molmil-images/mine/8wdt) | Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue) | Descriptor: | (2S,3S,4R,5R)-5-(6-amino-2-((E)-phenyldiazenyl)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide, Adenosine receptor A2a, Antibody Fab fragment heavy chain, ... | Authors: | Araya, T, Asada, H, Iwata, S, Im, D.H. | Deposit date: | 2023-09-16 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.34 Å) | Cite: | Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A 2A receptor. Biochem.Biophys.Res.Commun., 695, 2023
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5O2U
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![BU of 5o2u by Molmil](/molmil-images/mine/5o2u) | Llama VHH in complex with p24 | Descriptor: | Capsid protein p24, VHH 59H10 | Authors: | Caillat, C, Verrips, T, Weissenhorn, W. | Deposit date: | 2017-05-22 | Release date: | 2017-06-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Unravelling the Molecular Basis of High Affinity Nanobodies against HIV p24: In Vitro Functional, Structural, and in Silico Insights. ACS Infect Dis, 3, 2017
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5FXC
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![BU of 5fxc by Molmil](/molmil-images/mine/5fxc) | Crystal structure of glycopeptide 22 in complex with scFv-SM3 | Descriptor: | 1,2-ETHANEDIOL, GLYCOPEPTIDE, SCFV-SM3 | Authors: | Rojas-Ocariz, V, Companon, I, Aydillo, C, Castro-Lopez, J, Jimenez-Barbero, J, Hurtado-Guerrero, R, Avenoza, A, Zurbano, M.M, Corzana, F, Busto, J.H, Peregrina, J.M. | Deposit date: | 2016-02-29 | Release date: | 2016-06-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Design of Alpha-S-Glycopeptides Derived from Muc1 with a Flexible and Solvent Exposed Sugar Moiety J.Org.Chem., 81, 2016
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