7LWD

Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab

Summary for 7LWD

Entry DOI	10.2210/pdb7lwd/pdb
EMDB information	23545
Descriptor	Sodium-dependent serotonin transporter, heavy chain antibody fragment, light chain antibody fragment, ... (6 entities in total)
Functional Keywords	antidepressant, complex, transporter, antibody, transport protein, transport protein-immune system complex, transport protein/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	86761.87
Authors	Yang, D.,Kalenderoglou, I.E.,Gouaux, E.,Coleman, J.A.,Loland, C.J. (deposition date: 2021-03-01, release date: 2021-08-11, Last modification date: 2021-09-01)
Primary citation	Plenge, P.,Yang, D.,Salomon, K.,Laursen, L.,Kalenderoglou, I.E.,Newman, A.H.,Gouaux, E.,Coleman, J.A.,Loland, C.J. The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter. Nat Commun, 12:5063-5063, 2021 Cited by PubMed: 34417466 DOI: 10.1038/s41467-021-25363-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.65 Å)

Structure validation