7LWD
Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent serotonin transporter | polymer | 541 | 61062.1 | 1 | UniProt (P31645) Pfam (PF00209) | Homo sapiens (Human) | SERT,5HT transporter,5HTT,Solute carrier family 6 member 4 |
| 2 | B (H) | heavy chain antibody fragment | polymer | 118 | 12980.5 | 1 | Mus musculus | ||
| 3 | C (L) | light chain antibody fragment | polymer | 110 | 11776.1 | 1 | Mus musculus | ||
| 4 | D (A) | 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE | non-polymer | 280.4 | 1 | Chemie (IXX) | |||
| 5 | E (A) | 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide | non-polymer | 441.5 | 1 | Chemie (YG7) | |||
| 6 | F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 85818.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 943.1 | |
| All* | Total formula weight | 86761.9 |
