7S6D

CryoEM structure of modular PKS holo-Lsd14 bound to antibody fragment 1B2, composite structure

Summary for 7S6D

Entry DOI	10.2210/pdb7s6d/pdb
EMDB information	24869 24870 24871 24872 24873 24874 24875
Descriptor	6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Lsd14 Polyketide synthase fusion, Fab 1B2 heavy chain, Fab 1B2 light chain, ... (4 entities in total)
Functional Keywords	modular polyketide synthase, ketosynthase, ketoreductase, acyl carrier protein, biosynthetic protein
Biological source	Saccharopolyspora erythraea More
Total number of polymer chains	7
Total formula weight	627091.27
Authors	Bagde, S.R.,Kim, C.-Y.,Fromme, J.C. (deposition date: 2021-09-13, release date: 2021-11-03, Last modification date: 2021-11-17)
Primary citation	Bagde, S.R.,Mathews, I.I.,Fromme, J.C.,Kim, C.Y. Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374:723-729, 2021 Cited by PubMed: 34735234 DOI: 10.1126/science.abi8532 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation