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6VZ4
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BU of 6vz4 by Molmil
Cryo-EM structure of Sth1-Arp7-Arp9-Rtt102 bound to the nucleosome in ADP Beryllium Fluoride state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin-like protein ARP9, ...
Authors:Leschziner, A.E, Baker, R.W.
Deposit date:2020-02-27
Release date:2020-12-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural insights into assembly and function of the RSC chromatin remodeling complex.
Nat.Struct.Mol.Biol., 28, 2021
6O22
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BU of 6o22 by Molmil
Structure of Asf1-H3:H4-Rtt109-Vps75 histone chaperone-lysine acetyltransferase complex with the histone substrate.
Descriptor: Histone H3.2, Histone H4, Histone acetyltransferase RTT109, ...
Authors:Danilenko, N, Carlomagno, T, Kirkpatrick, J.P.
Deposit date:2019-02-22
Release date:2019-07-31
Last modified:2024-05-01
Method:SOLUTION NMR, SOLUTION SCATTERING
Cite:Histone chaperone exploits intrinsic disorder to switch acetylation specificity.
Nat Commun, 10, 2019
8HPO
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BU of 8hpo by Molmil
Cryo-EM structure of a SIN3/HDAC complex from budding yeast
Descriptor: Histone deacetylase RPD3, PHOSPHOTHREONINE, POTASSIUM ION, ...
Authors:Guo, Z, Zhan, X, Wang, C.
Deposit date:2022-12-12
Release date:2023-05-03
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structure of a SIN3-HDAC complex from budding yeast.
Nat.Struct.Mol.Biol., 30, 2023
1BMK
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BU of 1bmk by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655
Descriptor: 4-(FLUOROPHENYL)-1-CYCLOPROPYLMETHYL-5-(2-AMINO-4-PYRIMIDINYL)IMIDAZOLE, PROTEIN (MAP KINASE P38)
Authors:Wang, Z, Canagarajah, B, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-23
Release date:1999-07-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1BL6
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BU of 1bl6 by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995
Descriptor: 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE, PROTEIN (MAP KINASE P38)
Authors:Wang, Z, Canagarajah, B.J, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-11
Release date:1999-07-26
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
8OVW
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BU of 8ovw by Molmil
Cryo-EM structure of CBF1-CCAN bound topologically to centromeric DNA
Descriptor: C0N3 DNA, Centromere-binding protein 1, Inner kinetochore subunit AME1, ...
Authors:Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D.
Deposit date:2023-04-26
Release date:2023-08-09
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere.
Sci Adv, 9, 2023
6TE1
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BU of 6te1 by Molmil
Structure of the KDM1A/CoREST complex with the inhibitor 2-[3-{4-chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol
Descriptor: 5-[4-cyclobutyl-1-[2-(4-piperidin-4-yloxyphenoxy)ethyl]imidazol-2-yl]-4-methyl-thieno[3,2-b]pyrrole, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Pasqualato, S, Cecatiello, V.
Deposit date:2019-11-11
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.
Acs Med.Chem.Lett., 11, 2020
1BL7
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BU of 1bl7 by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025
Descriptor: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, PROTEIN (MAP KINASE P38)
Authors:Wang, Z, Canagarajah, B.J, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-23
Release date:1999-07-26
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
6PWV
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BU of 6pwv by Molmil
Cryo-EM structure of MLL1 core complex bound to the nucleosome
Descriptor: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ...
Authors:Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U.
Deposit date:2019-07-23
Release date:2019-12-18
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Nat Commun, 10, 2019
3KJL
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BU of 3kjl by Molmil
Sgf11:Sus1 complex
Descriptor: Protein SUS1, SAGA-associated factor 11
Authors:Stewart, M, Ellisdon, A.M.
Deposit date:2009-11-03
Release date:2009-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.
J.Biol.Chem., 285, 2010
3KIK
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BU of 3kik by Molmil
Sgf11:Sus1 complex
Descriptor: Protein SUS1, SAGA-associated factor 11
Authors:Stewart, M, Ellisdon, A.M.
Deposit date:2009-11-02
Release date:2009-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1
J.Biol.Chem., 285, 2010
8F2Z
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BU of 8f2z by Molmil
LSD1-CoREST in complex with AW2, short soaking
Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,13R)-3-([1,1'-biphenyl]-4-yl)-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name)
Authors:Caroli, J, Mattevi, A.
Deposit date:2022-11-09
Release date:2024-06-12
Last modified:2025-06-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.
Nat Commun, 16, 2025
8F30
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BU of 8f30 by Molmil
LSD1-CoREST in complex with AW2, long soaking
Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-{5-[3-([1,1'-biphenyl]-4-yl)propanoyl]-7,8-dimethyl-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name)
Authors:Caroli, J, Mattevi, A.
Deposit date:2022-11-09
Release date:2024-06-12
Last modified:2025-06-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.
Nat Commun, 16, 2025
8F59
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BU of 8f59 by Molmil
LSD1-CoREST in complex with AW2 and SNAG peptide
Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, Zinc finger protein SNAI1, ...
Authors:Caroli, J, Mattevi, A.
Deposit date:2022-11-12
Release date:2024-06-12
Last modified:2025-06-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.
Nat Commun, 16, 2025
8FJ4
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BU of 8fj4 by Molmil
LSD1-CoREST in complex with T108, short soaking
Descriptor: 3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-phenylbenzamide, Lysine-specific histone demethylase 1A, REST corepressor 1, ...
Authors:Caroli, J, Mattevi, A.
Deposit date:2022-12-19
Release date:2024-06-26
Last modified:2025-07-09
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.
Nat Commun, 16, 2025
8F6S
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BU of 8f6s by Molmil
LSD1-CoREST in complex with T105
Descriptor: 3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide, Lysine-specific histone demethylase 1A, REST corepressor 1, ...
Authors:Caroli, J, Mattevi, A.
Deposit date:2022-11-17
Release date:2024-06-12
Last modified:2025-06-25
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.
Nat Commun, 16, 2025
8FDV
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BU of 8fdv by Molmil
LSD1-CoREST in complex N-formyl FAD and SNAG peptide
Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, Zinc finger protein SNAI1, ...
Authors:Caroli, J, Mattevi, A.
Deposit date:2022-12-05
Release date:2024-06-12
Last modified:2025-06-25
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.
Nat Commun, 16, 2025
8FJ7
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BU of 8fj7 by Molmil
LSD1-CoREST in complex with T108 and SNAG peptide
Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, Zinc finger protein SNAI1, ...
Authors:Caroli, J, Mattevi, A.
Deposit date:2022-12-19
Release date:2024-06-26
Last modified:2025-07-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.
Nat Commun, 16, 2025
8UO5
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BU of 8uo5 by Molmil
Protein Phosphatase 2A B55 subunit in complex with IER5
Descriptor: FE (III) ION, Immediate early response gene 5 protein, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, ...
Authors:Jones, D.T.D, Cao, R, Rawson, S.D, Blacklow, S.C.
Deposit date:2023-10-19
Release date:2025-03-26
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Protein Phosphatase 2A B55 subunit in complex with IER5
To Be Published
5A9Q
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BU of 5a9q by Molmil
Human nuclear pore complex
Descriptor: NUCLEAR PORE COMPLEX PROTEIN NUP107, NUCLEAR PORE COMPLEX PROTEIN NUP133, NUCLEAR PORE COMPLEX PROTEIN NUP155, ...
Authors:von Appen, A, Kosinski, J, Sparks, L, Ori, A, DiGuilio, A, Vollmer, B, Mackmull, M, Banterle, N, Parca, L, Kastritis, P, Buczak, K, Mosalaganti, S, Hagen, W, Andres-Pons, A, Lemke, E.A, Bork, P, Antonin, W, Glavy, J.S, Bui, K.H, Beck, M.
Deposit date:2015-07-22
Release date:2015-09-30
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (23 Å)
Cite:In Situ Structural Analysis of the Human Nuclear Pore Complex
Nature, 526, 2015
5WVI
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BU of 5wvi by Molmil
The resting state of yeast proteasome
Descriptor: 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ...
Authors:Ding, Z, Cong, Y.
Deposit date:2016-12-25
Release date:2017-03-22
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx
Cell Res., 27, 2017
8BOX
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BU of 8box by Molmil
LSD1-CoREST in complex with AW4 and SNAG peptide
Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, Zinc finger protein SNAI1, ...
Authors:Caroli, J, Mattevi, A.
Deposit date:2022-11-15
Release date:2024-06-05
Last modified:2025-06-18
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.
Nat Commun, 16, 2025
8BOP
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BU of 8bop by Molmil
LSD1-CoREST in complex with AW4, long soaking
Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{S})-5-[7,8-dimethyl-2,4-bis(oxidanylidene)-5-[3-[4-(3-phenylphenyl)phenyl]propanoyl]-1~{H}-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate
Authors:Caroli, J, Mattevi, A.
Deposit date:2022-11-15
Release date:2024-06-05
Last modified:2025-06-18
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.
Nat Commun, 16, 2025
8WG5
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BU of 8wg5 by Molmil
Cryo-EM structure of USP16 bound to H2AK119Ub nucleosome
Descriptor: DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ...
Authors:Ai, H.S, He, Z.Z, Deng, Z.H, Liu, L.
Deposit date:2023-09-20
Release date:2023-12-27
Last modified:2024-11-27
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16.
Nat.Struct.Mol.Biol., 31, 2024
8FRV
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BU of 8frv by Molmil
LSD1-CoREST in complex with T17, short soaking
Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,13R)-3-[3-(dimethylcarbamoyl)phenyl]-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name)
Authors:Caroli, J, Mattevi, A.
Deposit date:2023-01-09
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1
To be published

238582

數據於2025-07-09公開中

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