8F59

LSD1-CoREST in complex with AW2 and SNAG peptide

Summary for 8F59

• Entry DOI: 10.2210/pdb8f59/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, Zinc finger protein SNAI1, ... (4 entities in total)
• Functional Keywords: epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 113609.55

Authors

Caroli, J.,Mattevi, A. (deposition date: 2022-11-12, release date: 2024-06-12)

• Primary citation: Caroli, J.,Mattevi, A.; Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1; to be published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)