2QMG
 
 | | Structure of BACE Bound to SCH745966 | | Descriptor: | Beta-secretase 1, D(-)-TARTARIC ACID, N-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-[(2R,4R)-4-PHENOXYPYRROLIDIN-2-YL]ETHYL}-3-{[(2R)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]CARBONYL}-5-METHYLBENZAMIDE | | Authors: | Strickland, C.O, Iserloh, U. | | Deposit date: | 2007-07-16 | | Release date: | 2008-03-18 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor.
Bioorg.Med.Chem.Lett., 18, 2008
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2QMH
 | | structure of V267F mutant HprK/P | | Descriptor: | HPr kinase/phosphorylase | | Authors: | Chaptal, V, Vincent, F, Gueguen-Chaignon, V, Poncet, S, Deutscher, J, Nessler, S, Morera, S. | | Deposit date: | 2007-07-16 | | Release date: | 2007-09-18 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Analysis of the Bacterial HPr Kinase/Phosphorylase V267F Mutant Gives Insights into the Allosteric Regulation Mechanism of This Bifunctional Enzyme.
J.Biol.Chem., 282, 2007
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2QMI
 | | Structure of the octameric penicillin-binding protein homologue from Pyrococcus abyssi | | Descriptor: | 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, LUTETIUM (III) ION, Pbp related beta-lactamase | | Authors: | Delfosse, V, Girard, E, Moulinier, L, Schultz, P, Mayer, C. | | Deposit date: | 2007-07-16 | | Release date: | 2008-07-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of the archaeal pab87 peptidase reveals a novel self-compartmentalizing protease family
Plos One, 4, 2009
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2QMJ
 | | Crystral Structure of the N-terminal Subunit of Human Maltase-Glucoamylase in Complex with Acarbose | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | | Authors: | Sim, L, Rose, D.R. | | Deposit date: | 2007-07-16 | | Release date: | 2008-01-08 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity
J.Mol.Biol., 375, 2008
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2QMK
 | | Human pancreatic alpha-amylase complexed with nitrite | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NITRITE ION, ... | | Authors: | Williams, L.K, Maurus, R, Brayer, G.D. | | Deposit date: | 2007-07-16 | | Release date: | 2008-03-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Alternative catalytic anions differentially modulate human alpha-amylase activity and specificity
Biochemistry, 47, 2008
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2QML
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2QMM
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2QMO
 | | Crystal structure of dethiobiotin synthetase (bioD) from Helicobacter pylori | | Descriptor: | CHLORIDE ION, Dethiobiotin synthetase | | Authors: | Chruszcz, M, Xu, X, Cuff, M, Cymborowski, M, Zheng, H, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2007-07-16 | | Release date: | 2007-07-31 | | Last modified: | 2022-04-13 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members.
Febs J., 279, 2012
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2QMP
 | | Crystal Structure of HIV-1 protease complexed with PL-100 | | Descriptor: | N-[(5S)-5-{[(4-aminophenyl)sulfonyl](isobutyl)amino}-6-hydroxyhexyl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamide, Pol polyprotein | | Authors: | Allison, T.J. | | Deposit date: | 2007-07-16 | | Release date: | 2008-07-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of HIV-1 protease complexed with PL-100
To be Published
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2QMQ
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2QMR
 | | Karyopherin beta2/transportin | | Descriptor: | Transportin-1 | | Authors: | Cansizoglu, A.E, Chook, Y.M. | | Deposit date: | 2007-07-16 | | Release date: | 2007-10-30 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Conformational heterogeneity of karyopherin beta2 is segmental
Structure, 15, 2007
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2QMS
 | | Crystal structure of a signaling molecule | | Descriptor: | Growth factor receptor-bound protein 7, SULFATE ION | | Authors: | Porter, C.J, Wilce, M.C, Wilce, J.A. | | Deposit date: | 2007-07-16 | | Release date: | 2008-07-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.
Bmc Struct.Biol., 7, 2007
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2QMT
 | | Crystal Polymorphism of Protein GB1 Examined by Solid-state NMR and X-ray Diffraction | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, ISOPROPYL ALCOHOL, Immunoglobulin G-binding protein G, ... | | Authors: | Frericks Schmidt, H.L, Sperling, L.J, Gao, Y.G, Wylie, B.J, Boettcher, J.M, Wilson, S.R, Rienstra, C.M. | | Deposit date: | 2007-07-16 | | Release date: | 2007-12-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.05 Å) | | Cite: | Crystal Polymorphism of Protein GB1 Examined by Solid-State NMR Spectroscopy and X-ray Diffraction.
J.Phys.Chem.B, 111, 2007
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2QMU
 | | Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, Translation initiation factor 2 alpha subunit, ... | | Authors: | Yatime, L, Mechulam, Y, Blanquet, S, Schmitt, E. | | Deposit date: | 2007-07-17 | | Release date: | 2007-11-06 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2QMV
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2QMW
 | | The crystal structure of the prephenate dehydratase (PDT) from Staphylococcus aureus subsp. aureus Mu50 | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Tan, K, Zhang, R, Li, H, Gu, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2007-07-17 | | Release date: | 2007-08-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structures of open (R) and close (T) states of prephenate dehydratase (PDT) - implication of allosteric regulation by L-phenylalanine.
J.Struct.Biol., 162, 2008
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2QMX
 | | The crystal structure of L-Phe inhibited prephenate dehydratase from Chlorobium tepidum TLS | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, PHENYLALANINE, ... | | Authors: | Tan, K, Li, H, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2007-07-17 | | Release date: | 2007-08-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structures of open (R) and close (T) states of prephenate dehydratase (PDT) - implication of allosteric regulation by L-phenylalanine.
J.Struct.Biol., 162, 2008
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2QMY
 | | Quinone Reductase 2 in complex with adrenochrome | | Descriptor: | (3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione, FLAVIN-ADENINE DINUCLEOTIDE, Ribosyldihydronicotinamide dehydrogenase, ... | | Authors: | Zhang, Z, Fu, Y, Buryanovskky, L. | | Deposit date: | 2007-07-17 | | Release date: | 2008-06-24 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Quinone Reductase 2 regulates Catecholamine oxidation
To be Published
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2QMZ
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2QN0
 | | Structure of Botulinum neurotoxin serotype C1 light chain protease | | Descriptor: | Neurotoxin, ZINC ION | | Authors: | Jin, R, Sikorra, S, Stegmann, C.M, Pich, A, Binz, T, Brunger, A.T. | | Deposit date: | 2007-07-17 | | Release date: | 2007-09-11 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.
Biochemistry, 46, 2007
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2QN1
 | | Glycogen Phosphorylase b in complex with asiatic acid | | Descriptor: | Glycogen phosphorylase, muscle form, asiatic acid | | Authors: | Zographos, S.E, Leonidas, D.D, Alexacou, K.-M, Hayes, J, Oikonomakos, N.G. | | Deposit date: | 2007-07-17 | | Release date: | 2008-06-03 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies
J.Med.Chem., 51, 2008
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2QN2
 | | Glycogen Phosphorylase b in complex with Maslinic Acid | | Descriptor: | Glycogen phosphorylase, muscle form, maslinic acid | | Authors: | Zographos, S.E, Leonidas, D.D, Alexacou, K.-M, Hayes, J, Oikonomakos, N.G. | | Deposit date: | 2007-07-17 | | Release date: | 2008-06-03 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.698 Å) | | Cite: | Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies
J.Med.Chem., 51, 2008
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2QN3
 | | Glycogen Phosphorylase in complex with N-4-chlorobenzoyl-N-beta-D-glucopyranosyl urea | | Descriptor: | Glycogen phosphorylase, muscle form, N-{[(4-chlorophenyl)carbonyl]carbamoyl}-beta-D-glucopyranosylamine | | Authors: | Chrysina, E.D, Tiraidis, C, Alexacou, K.-M, Zographos, S.E, Leonidas, D.D, Oikonomakos, N.G. | | Deposit date: | 2007-07-17 | | Release date: | 2008-07-22 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation
To be Published
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2QN4
 | | Structure and function study of rice bifunctional alpha-amylase/subtilisin inhibitor from Oryza sativa | | Descriptor: | Alpha-amylase/subtilisin inhibitor | | Authors: | Peng, W.Y, Lin, Y.H, Huang, Y.C, Guan, H.H, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2007-07-18 | | Release date: | 2008-07-22 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure and Function Study of Rice Bifunctional Alpha-Amylase/Subtilisin Inhibitor from Oryza Sativa
To be Published
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2QN5
 | | Crystal Structure and Functional Study of the Bowman-Birk Inhibitor from Rice Bran in Complex with Bovine Trypsin | | Descriptor: | Bowman-Birk type bran trypsin inhibitor, Cationic trypsin | | Authors: | Li, H.T, Lin, Y.H, Guan, H.H, Hsieh, Y.C, Wang, A.H.J, Chen, C.J. | | Deposit date: | 2007-07-18 | | Release date: | 2008-07-22 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal Structure and Functional Study of the Bowman-Birk Inhibitor from Rice Bran in Complex with Bovine Trypsin
To be Published
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