2QMJ

Crystral Structure of the N-terminal Subunit of Human Maltase-Glucoamylase in Complex with Acarbose

Summary for 2QMJ

Entry DOI	10.2210/pdb2qmj/pdb
Related	2QLY
Related PRD ID	PRD_900007
Descriptor	Maltase-glucoamylase, intestinal, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (7 entities in total)
Functional Keywords	hydrolase, glycosyl hydrolase family 31, glycoprotein, glycosidase, membrane, multifunctional enzyme, signal-anchor, sulfation, transmembrane
Biological source	Homo sapiens (human)
Cellular location	Apical cell membrane; Single-pass type II membrane protein: O43451
Total number of polymer chains	1
Total formula weight	101023.32
Authors	Sim, L.,Rose, D.R. (deposition date: 2007-07-16, release date: 2008-01-08, Last modification date: 2023-08-30)
Primary citation	Sim, L.,Quezada-Calvillo, R.,Sterchi, E.E.,Nichols, B.L.,Rose, D.R. Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity J.Mol.Biol., 375:782-792, 2008 Cited by PubMed: 18036614 DOI: 10.1016/j.jmb.2007.10.069 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation