2QMG

Structure of BACE Bound to SCH745966

Summary for 2QMG

Entry DOI	10.2210/pdb2qmg/pdb
Related	2qk5 2qkj 2qmd 2qmf 2qp8
Descriptor	Beta-secretase 1, N-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-[(2R,4R)-4-PHENOXYPYRROLIDIN-2-YL]ETHYL}-3-{[(2R)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]CARBONYL}-5-METHYLBENZAMIDE, D(-)-TARTARIC ACID, ... (4 entities in total)
Functional Keywords	bace1, protease, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, transmembrane, zymogen
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	2
Total formula weight	89394.67
Authors	Strickland, C.O.,Iserloh, U. (deposition date: 2007-07-16, release date: 2008-03-18, Last modification date: 2017-10-25)
Primary citation	Iserloh, U.,Pan, J.,Stamford, A.W.,Kennedy, M.E.,Zhang, Q.,Zhang, L.,Parker, E.M.,McHugh, N.A.,Favreau, L.,Strickland, C.,Voigt, J. Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor. Bioorg.Med.Chem.Lett., 18:418-422, 2008 Cited by PubMed: 17980584 DOI: 10.1016/j.bmcl.2007.10.053 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation