2QMG
Structure of BACE Bound to SCH745966
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Beta-secretase 1 | polymer | 395 | 43939.6 | 2 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (human) | Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Memapsin-2, Aspartyl protease 2, Asp 2, ASP2 |
| 2 | A, B | N-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-[(2R,4R)-4-PHENOXYPYRROLIDIN-2-YL]ETHYL}-3-{[(2R)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]CARBONYL}-5-METHYLBENZAMIDE | non-polymer | 607.7 | 2 | Chemie (SC6) | |||
| 3 | A, B | D(-)-TARTARIC ACID | non-polymer | 150.1 | 2 | Chemie (TAR) | |||
| 4 | water | water | 18.0 | 921 | Chemie (HOH) |
Sequence modifications
A, B: 55 - 447 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Ala 53 | - | EXPRESSION TAG |
| Ala 54 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 87879.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1515.5 | |
| All* | Total formula weight | 89394.7 |
