2QMD

Structure of BACE Bound to SCH722924

Summary for 2QMD

Entry DOI	10.2210/pdb2qmd/pdb
Related	2qk5 2qkj 2qmf 2qmg 2qp8
Descriptor	Beta-secretase 1, D(-)-TARTARIC ACID, N'-[(1S,2R)-2-[(2R,4R)-4-(BENZYLOXY)PYRROLIDIN-2-YL]-1-(3,5-DIFLUOROBENZYL)-2-HYDROXYETHYL]-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE, ... (4 entities in total)
Functional Keywords	bace1, protease, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, transmembrane, zymogen
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	2
Total formula weight	89544.84
Authors	Strickland, C.O.,Iserloh, U. (deposition date: 2007-07-16, release date: 2008-03-11, Last modification date: 2017-10-25)
Primary citation	Iserloh, U.,Wu, Y.,Cumming, J.N.,Pan, J.,Wang, L.Y.,Stamford, A.W.,Kennedy, M.E.,Kuvelkar, R.,Chen, X.,Parker, E.M.,Strickland, C.,Voigt, J. Potent pyrrolidine- and piperidine-based BACE-1 inhibitors. Bioorg.Med.Chem.Lett., 18:414-417, 2008 Cited by PubMed: 18023580 DOI: 10.1016/j.bmcl.2007.10.116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation