2QMD
Structure of BACE Bound to SCH722924
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Beta-secretase 1 | polymer | 395 | 43939.6 | 2 | UniProt (P56817) Pfam (PF00026) | Homo sapiens (human) | Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Memapsin-2, Aspartyl protease 2, Asp 2, ASP2 |
| 2 | C, E, G (A, B) | D(-)-TARTARIC ACID | non-polymer | 150.1 | 3 | Chemie (TAR) | |||
| 3 | D, F (A, B) | N'-[(1S,2R)-2-[(2R,4R)-4-(BENZYLOXY)PYRROLIDIN-2-YL]-1-(3,5-DIFLUOROBENZYL)-2-HYDROXYETHYL]-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE | non-polymer | 607.7 | 2 | Chemie (CS7) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 977 | Chemie (HOH) |
Sequence modifications
A, B: 55 - 447 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Ala 53 | - | expression tag |
| Ala 54 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 87879.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1665.7 | |
| All* | Total formula weight | 89544.8 |
