2QMD
Structure of BACE Bound to SCH722924
Summary for 2QMD
Entry DOI | 10.2210/pdb2qmd/pdb |
Related | 2qk5 2qkj 2qmf 2qmg 2qp8 |
Descriptor | Beta-secretase 1, D(-)-TARTARIC ACID, N'-[(1S,2R)-2-[(2R,4R)-4-(BENZYLOXY)PYRROLIDIN-2-YL]-1-(3,5-DIFLUOROBENZYL)-2-HYDROXYETHYL]-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE, ... (4 entities in total) |
Functional Keywords | bace1, protease, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, transmembrane, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 2 |
Total formula weight | 89544.84 |
Authors | Strickland, C.O.,Iserloh, U. (deposition date: 2007-07-16, release date: 2008-03-11, Last modification date: 2017-10-25) |
Primary citation | Iserloh, U.,Wu, Y.,Cumming, J.N.,Pan, J.,Wang, L.Y.,Stamford, A.W.,Kennedy, M.E.,Kuvelkar, R.,Chen, X.,Parker, E.M.,Strickland, C.,Voigt, J. Potent pyrrolidine- and piperidine-based BACE-1 inhibitors. Bioorg.Med.Chem.Lett., 18:414-417, 2008 Cited by PubMed: 18023580DOI: 10.1016/j.bmcl.2007.10.116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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