5FI9
| Closed form of murine Acid Sphingomyelinase in complex with bisphosphonate inhibitor AbPA | Descriptor: | (1-azanyl-1-phosphono-decyl)phosphonic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorelik, A, Illes, K, Heinz, L.X, Superti-Furga, G, Nagar, B. | Deposit date: | 2015-12-22 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.543 Å) | Cite: | Crystal structure of mammalian acid sphingomyelinase. Nat Commun, 7, 2016
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5FC1
| Murine SMPDL3A in complex with sulfate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorelik, A, Illes, K, Superti-Furga, G, Nagar, B. | Deposit date: | 2015-12-14 | Release date: | 2016-01-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.389 Å) | Cite: | Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A. J.Biol.Chem., 291, 2016
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5FIB
| Open form of murine Acid Sphingomyelinase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorelik, A, Illes, K, Heinz, L.X, Superti-Furga, G, Nagar, B. | Deposit date: | 2015-12-22 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of mammalian acid sphingomyelinase. Nat Commun, 7, 2016
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5H7W
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5HQN
| Catalytic domain of murine Acid Sphingomyelinase (ASMase, ASM, SMPD1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorelik, A, Illes, K, Heinz, L.X, Superti-Furga, G, Nagar, B. | Deposit date: | 2016-01-21 | Release date: | 2016-07-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of mammalian acid sphingomyelinase. Nat Commun, 7, 2016
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5HPE
| Phosphatase domain of PP5 bound to a phosphomimetic Cdc37 substrate peptide | Descriptor: | COBALT HEXAMMINE(III), MANGANESE (II) ION, Serine/threonine-protein phosphatase 5,Hsp90 co-chaperone Cdc37 | Authors: | Oberoi, J, Mariotti, L, Vaughan, C. | Deposit date: | 2016-01-20 | Release date: | 2016-07-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structural and functional basis of protein phosphatase 5 substrate specificity. Proc.Natl.Acad.Sci.USA, 113, 2016
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5INB
| RepoMan-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex | Descriptor: | Cell division cycle-associated protein 2, GLYCEROL, MALONATE ION, ... | Authors: | Kumar, G.S, Peti, W, Page, R. | Deposit date: | 2016-03-07 | Release date: | 2016-10-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism. Elife, 5, 2016
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5I8R
| aSMase with zinc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sphingomyelin phosphodiesterase, ... | Authors: | Zhou, Y.F, Wei, R.R. | Deposit date: | 2016-02-19 | Release date: | 2016-09-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.646 Å) | Cite: | Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease. Nat Commun, 7, 2016
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8GAE
| Hsp90 provides platform for CRaf dephosphorylation by PP5 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... | Authors: | Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. | Deposit date: | 2023-02-22 | Release date: | 2023-04-26 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun, 14, 2023
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8GFT
| Hsp90 provides platform for CRaf dephosphorylation by PP5 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... | Authors: | Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. | Deposit date: | 2023-03-08 | Release date: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun, 14, 2023
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7TVF
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7TXH
| Human MRas Q71R in complex with human Shoc2 LRR domain M173I and human PP1Ca | Descriptor: | GLYCEROL, Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, ... | Authors: | Hauseman, Z.J, Viscomi, J, Dhembi, A, Clark, K, King, D.A, Fodor, M. | Deposit date: | 2022-02-09 | Release date: | 2022-06-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of the MRAS-SHOC2-PP1C phosphatase complex. Nature, 609, 2022
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7UPI
| Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex | Descriptor: | CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, Leucine-rich repeat protein SHOC-2, ... | Authors: | Fuller, J.R, Hajian, B, Lemke, C, Kwon, J, Bian, Y, Aguirre, A. | Deposit date: | 2022-04-15 | Release date: | 2022-05-04 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature, 609, 2022
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7YCX
| The structure of INTAC-PEC complex | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y. | Deposit date: | 2022-07-02 | Release date: | 2023-03-15 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Structural basis of INTAC-regulated transcription. Protein Cell, 14, 2023
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4V0U
| The crystal structure of ternary PP1G-PPP1R15B and G-actin complex | Descriptor: | ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. | Deposit date: | 2014-09-18 | Release date: | 2015-03-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (7.88 Å) | Cite: | G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases. Elife, 4, 2015
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7ZR5
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7ZR6
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8B5R
| p97-p37-SPI substrate complex | Descriptor: | I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ... | Authors: | van den Boom, J, Marini, G, Meyer, H, Saibil, H. | Deposit date: | 2022-09-24 | Release date: | 2023-06-07 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (6.1 Å) | Cite: | Structural basis of ubiquitin-independent PP1 complex disassembly by p97. Embo J., 42, 2023
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8RBX
| Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | Authors: | Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. | Deposit date: | 2023-12-05 | Release date: | 2024-02-07 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 629, 2024
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6GHM
| Structure of PP1 alpha phosphatase bound to ASPP2 | Descriptor: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Apoptosis-stimulating of p53 protein 2, ... | Authors: | Mouilleron, S, Bertran, T.M, Tapon, N, Zhou, Y. | Deposit date: | 2018-05-08 | Release date: | 2019-02-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail. Nat Commun, 10, 2019
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7SD0
| Cryo-EM structure of the SHOC2:PP1C:MRAS complex | Descriptor: | Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, MANGANESE (II) ION, ... | Authors: | Liau, N.P.D, Johnson, M.C, Hymowitz, S.G, Sudhamsu, J. | Deposit date: | 2021-09-29 | Release date: | 2022-04-20 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural basis for SHOC2 modulation of RAS signalling. Nature, 609, 2022
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7SQC
| Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ... | Authors: | Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R. | Deposit date: | 2021-11-05 | Release date: | 2022-04-13 | Last modified: | 2022-06-08 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Ciliary central apparatus structure reveals mechanisms of microtubule patterning. Nat.Struct.Mol.Biol., 29, 2022
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4IL1
| Crystal Structure of the Rat Calcineurin | Descriptor: | CALCIUM ION, Calmodulin, Calcineurin subunit B type 1, ... | Authors: | Ye, Q, Faucher, F, Jia, Z. | Deposit date: | 2012-12-28 | Release date: | 2013-10-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of calcineurin activation by calmodulin. Cell Signal, 25, 2013
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7N6G
| C1 of central pair | Descriptor: | CPC1, Calmodulin, DPY30, ... | Authors: | Han, L, Zhang, K. | Deposit date: | 2021-06-08 | Release date: | 2022-05-18 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of an active central apparatus. Nat.Struct.Mol.Biol., 29, 2022
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7NZM
| Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Yan, Y, Hardwick, S, Ron, D. | Deposit date: | 2021-03-24 | Release date: | 2021-09-29 | Last modified: | 2021-10-20 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Higher-order phosphatase-substrate contacts terminate the integrated stress response. Nat.Struct.Mol.Biol., 28, 2021
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