5JG8
Crystal structure of human acid sphingomyelinase
Summary for 5JG8
Entry DOI | 10.2210/pdb5jg8/pdb |
Descriptor | Sphingomyelin phosphodiesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | lysosomal hydrolase, neimann-pick disease, sphingolipid, saposin, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 135427.76 |
Authors | Xiong, Z.J.,Prive, G.G. (deposition date: 2016-04-19, release date: 2016-07-06, Last modification date: 2023-09-27) |
Primary citation | Xiong, Z.J.,Huang, J.,Poda, G.,Pomes, R.,Prive, G.G. Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis. J.Mol.Biol., 428:3026-3042, 2016 Cited by PubMed: 27349982DOI: 10.1016/j.jmb.2016.06.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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