5JG8
Crystal structure of human acid sphingomyelinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Sphingomyelin phosphodiesterase | polymer | 586 | 65323.5 | 2 | UniProt (P17405) Pfam (PF00149) Pfam (PF19272) | Homo sapiens (Human) | Acid sphingomyelinase,aSMase |
| 2 | C, D, H, I (C, D, H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | E (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G79924RM) | |||
| 4 | F, G (F, G) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G62182OO) | |||
| 5 | J, K, P, Q (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 6 | L, R (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 7 | M, N, O, S, T (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) |
Sequence modifications
A, B: 47 - 629 (UniProt: P17405)
| PDB | External Database | Details |
|---|---|---|
| Gly 44 | - | expression tag |
| Ala 45 | - | expression tag |
| Pro 46 | - | expression tag |
| Ser 629 | Cys 629 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 130646.9 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 3295.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1485.8 | |
| All* | Total formula weight | 135427.8 |
