2HD5
| USP2 in complex with ubiquitin | Descriptor: | Polyubiquitin, Ubiquitin carboxyl-terminal hydrolase 2, ZINC ION | Authors: | Renatus, M, Kroemer, M. | Deposit date: | 2006-06-20 | Release date: | 2006-08-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural Basis of Ubiquitin Recognition by the Deubiquitinating Protease USP2. Structure, 14, 2006
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5ZBI
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5ZQ7
| SidE-Ubi-NAD | Descriptor: | ADENOSINE MONOPHOSPHATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SidE, ... | Authors: | Wang, Y, Gao, A, Gao, P. | Deposit date: | 2018-04-17 | Release date: | 2018-05-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.847 Å) | Cite: | Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE. Cell, 173, 2018
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2L00
| Solution structure of the non-covalent complex of the ZNF216 A20 domain with ubiquitin | Descriptor: | Ubiquitin, ZINC ION, Zfand5 protein (Zinc finger protein 216 (Predicted), ... | Authors: | Garner, T.P, Long, J.E, Searle, M.S, Layfield, R. | Deposit date: | 2010-06-29 | Release date: | 2011-07-20 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Co-localisation of ubiquitin receptors ZNF216 and p62 in a ubiquitin-mediated ternary complex To be Published
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2L0F
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2NBW
| Solution structure of the Rpn1 T1 site with the Rad23 UBL domain | Descriptor: | 26S proteasome regulatory subunit RPN1, UV excision repair protein RAD23 | Authors: | Chen, X, Walters, K.J. | Deposit date: | 2016-03-14 | Release date: | 2016-07-20 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome. Structure, 24, 2016
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2HTH
| Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain | Descriptor: | Ubiquitin, Vacuolar protein sorting protein 36 | Authors: | Alam, S.L, Whitby, F.G, Hill, C.P, Sundquist, W.I. | Deposit date: | 2006-07-25 | Release date: | 2006-10-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. Nat.Struct.Mol.Biol., 13, 2006
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2MRO
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2MUR
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2JY6
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2NBV
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2L0T
| Solution structure of the complex of ubiquitin and the VHS domain of Stam2 | Descriptor: | Signal transducing adapter molecule 2, Ubiquitin | Authors: | Lange, A, Hoeller, D, Wienk, H, Marcillat, O, Lancelin, J, Walker, O. | Deposit date: | 2010-07-15 | Release date: | 2010-12-15 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR reveals a different mode of binding of the Stam2 VHS domain to ubiquitin and diubiquitin. Biochemistry, 50, 2011
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2QHO
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8BS9
| Structure of USP36 in complex with Ubiquitin-PA | Descriptor: | Polyubiquitin-B, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 36, ... | Authors: | O'Dea, R, Gersch, M. | Deposit date: | 2022-11-24 | Release date: | 2023-07-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36. Nat.Chem.Biol., 19, 2023
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8BS3
| Structure of USP36 in complex with Fubi-PA | Descriptor: | 40S ribosomal protein S30, Ubiquitin carboxyl-terminal hydrolase 36, ZINC ION, ... | Authors: | O'Dea, R, Gersch, M. | Deposit date: | 2022-11-24 | Release date: | 2023-07-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36. Nat.Chem.Biol., 19, 2023
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8C13
| Crystal structure of pVHL:ElonginC:ElonginB complex bound to PROTAC JW48 | Descriptor: | (2~{S},4~{R})-1-[(2~{S})-2-[3-[2-[2-[2-(acetamidomethyl)-4-(6,7-dihydro-5~{H}-pyrrolo[1,2-a]imidazol-2-yl)phenoxy]ethoxy]ethoxy]propanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Kraemer, A, Weckesser, J, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2022-12-20 | Release date: | 2022-12-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30, 2023
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8C07
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8CX9
| Structure of the SARS-COV2 PLpro (C111S) in complex with a dimeric Ubv that inhibits activity by an unusual allosteric mechanism | Descriptor: | BROMIDE ION, CHLORIDE ION, Papain-like protease nsp3, ... | Authors: | Singer, A.U, Slater, C.L, Patel, A, Russel, R, Mark, B.L, Sidhu, S.S. | Deposit date: | 2022-05-20 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site. Plos Pathog., 18, 2022
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8CX2
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2 | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8CX0
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8CX1
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1 | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8B7F
| Nuclease from C. glutamicum | Descriptor: | Ubiquitin-like protein SMT3,MksG | Authors: | Wehenkel, A, Ben Assaya, M, Haouz, A. | Deposit date: | 2022-09-29 | Release date: | 2023-03-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (4.6 Å) | Cite: | The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG. Nucleic Acids Res., 51, 2023
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8CQL
| pVHL:EloB:EloC in complex with (2S,4R)-N-((S)-1-(5-Fluoro-2-methoxy-4-(4-methylthiazol-5-yl)phenyl)ethyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide (Compound 33) | Descriptor: | (2~{S},4~{R})-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[(1~{S})-1-[5-fluoranyl-2-methoxy-4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Casement, R, Phuong Vu, L, Ciulli, A, Gutschow, M. | Deposit date: | 2023-03-06 | Release date: | 2023-09-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1 alpha Stabilizers. J.Med.Chem., 66, 2023
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8CAF
| N8C_Fab3b in complex with NEDD8-CUL1(WHB) | Descriptor: | Cullin-1, Fab Heavy Chain, Fab Light Chain, ... | Authors: | Duda, D.M, Yanishevski, D, Henneberg, L.T, Schulman, B.A. | Deposit date: | 2023-01-24 | Release date: | 2023-09-13 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Activity-based profiling of cullin-RING E3 networks by conformation-specific probes. Nat.Chem.Biol., 19, 2023
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8CQK
| pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(2-methyl-4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide (Compound 30) | Descriptor: | (2~{S},4~{R})-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[(1~{S})-1-[2-methyl-4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Casement, R, Phuong Vu, L, Ciulli, A, Gutschow, M. | Deposit date: | 2023-03-06 | Release date: | 2023-09-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1 alpha Stabilizers. J.Med.Chem., 66, 2023
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