8C13

Crystal structure of pVHL:ElonginC:ElonginB complex bound to PROTAC JW48

Summary for 8C13

Entry DOI	10.2210/pdb8c13/pdb
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
Functional Keywords	e3 ligase, protac, vhl, structural genomics, structural genomics consortium, sgc, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	45035.11
Authors	Kraemer, A.,Weckesser, J.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-12-20, release date: 2022-12-28, Last modification date: 2023-11-22)
Primary citation	Schwalm, M.P.,Kramer, A.,Dolle, A.,Weckesser, J.,Yu, X.,Jin, J.,Saxena, K.,Knapp, S. Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30:753-765.e8, 2023 Cited by PubMed: 37354907 DOI: 10.1016/j.chembiol.2023.06.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation