8C13
Crystal structure of pVHL:ElonginC:ElonginB complex bound to PROTAC JW48
Summary for 8C13
Entry DOI | 10.2210/pdb8c13/pdb |
Descriptor | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total) |
Functional Keywords | e3 ligase, protac, vhl, structural genomics, structural genomics consortium, sgc, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 45035.11 |
Authors | Kraemer, A.,Weckesser, J.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-12-20, release date: 2022-12-28, Last modification date: 2023-11-22) |
Primary citation | Schwalm, M.P.,Kramer, A.,Dolle, A.,Weckesser, J.,Yu, X.,Jin, J.,Saxena, K.,Knapp, S. Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30:753-765.e8, 2023 Cited by PubMed: 37354907DOI: 10.1016/j.chembiol.2023.06.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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