8C13

Crystal structure of pVHL:ElonginC:ElonginB complex bound to PROTAC JW48

Functional Information from GO Data

Chain	GOid	namespace	contents
J	0001222	molecular_function	transcription corepressor binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005829	cellular_component	cytosol
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0016567	biological_process	protein ubiquitination
J	0030891	cellular_component	VCB complex
J	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
J	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
J	0065003	biological_process	protein-containing complex assembly
J	0070449	cellular_component	elongin complex
J	0140958	biological_process	target-directed miRNA degradation
K	0001222	molecular_function	transcription corepressor binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005829	cellular_component	cytosol
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0006367	biological_process	transcription initiation at RNA polymerase II promoter
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0016567	biological_process	protein ubiquitination
K	0030674	molecular_function	protein-macromolecule adaptor activity
K	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
K	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
K	0070449	cellular_component	elongin complex
K	0140958	biological_process	target-directed miRNA degradation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378

Chain	Residue	Details
J	MET1

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62869

Chain	Residue	Details
J	THR84

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62869

Chain	Residue	Details
J	SER108
J	SER111

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