8CX2

Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2

Summary for 8CX2

• Entry DOI: 10.2210/pdb8cx2/pdb
• EMDB information: 27032 27033 27034
• Descriptor: DNA dC->dU-editing enzyme APOBEC-3G, Virion infectivity factor, Core-binding factor subunit beta, ... (8 entities in total)
• Functional Keywords: viral protein, rna binding protein, complex, ubiquitin e3 ligase, viral protein-immune system-rna complex, viral protein/immune system/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 245621.41

Authors

Li, Y.,Langley, C.,Azumaya, C.M.,Echeverria, I.,Chesarino, N.M.,Emerman, M.,Cheng, Y.,Gross, J.D. (deposition date: 2022-05-19, release date: 2023-02-15, Last modification date: 2023-04-05)

• Primary citation: Li, Y.L.,Langley, C.A.,Azumaya, C.M.,Echeverria, I.,Chesarino, N.M.,Emerman, M.,Cheng, Y.,Gross, J.D.; The structural basis for HIV-1 Vif antagonism of human APOBEC3G.; Nature, 615:728-733, 2023; PubMed: 36754086; DOI: 10.1038/s41586-023-05779-1

Experimental method

ELECTRON MICROSCOPY (3.2 Å)