8CQK

pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(2-methyl-4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide (Compound 30)

Summary for 8CQK

Entry DOI	10.2210/pdb8cqk/pdb
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
Functional Keywords	inhibitor, e3 ligase complex, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	12
Total formula weight	169127.77
Authors	Casement, R.,Phuong Vu, L.,Ciulli, A.,Gutschow, M. (deposition date: 2023-03-06, release date: 2023-09-27, Last modification date: 2023-10-11)
Primary citation	Vu, L.P.,Diehl, C.J.,Casement, R.,Bond, A.G.,Steinebach, C.,Strasek, N.,Bricelj, A.,Perdih, A.,Schnakenburg, G.,Sosic, I.,Ciulli, A.,Gutschow, M. Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1 alpha Stabilizers. J.Med.Chem., 66:12776-12811, 2023 Cited by PubMed: 37708384 DOI: 10.1021/acs.jmedchem.3c00434 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.62 Å)

Structure validation