2Z2S
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7KTP
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![BU of 7ktp by Molmil](/molmil-images/mine/7ktp) | PRC2:EZH1_B from a dimeric PRC2 bound to a nucleosome | Descriptor: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | Authors: | Grau, D.J, Armache, K.J. | Deposit date: | 2020-11-24 | Release date: | 2021-02-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
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7YHJ
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3DEU
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![BU of 3deu by Molmil](/molmil-images/mine/3deu) | Crystal structure of transcription regulatory protein slyA from Salmonella typhimurium in complex with salicylate ligands | Descriptor: | 2-HYDROXYBENZOIC ACID, Transcriptional regulator slyA | Authors: | Le Trong, I, Brzovic, P.S, Fang, F.C, Libby, S.J, Stenkamp, R.E. | Deposit date: | 2008-06-10 | Release date: | 2008-06-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Evolution of SlyA/RovA Transcription Factors from Repressors to Countersilencers in Enterobacteriaceae . Mbio, 10, 2019
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5FA5
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3BT9
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3BTI
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2FJ1
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![BU of 2fj1 by Molmil](/molmil-images/mine/2fj1) | Crystal Structure Analysis of Tet Repressor (class D) in Complex with 7-Chlortetracycline-Nickel(II) | Descriptor: | 7-CHLOROTETRACYCLINE, CHLORIDE ION, NICKEL (II) ION, ... | Authors: | Orth, P, Saenger, W, Palm, G.J, Hinrichs, W. | Deposit date: | 2005-12-30 | Release date: | 2007-01-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex. J.Biol.Inorg.Chem., 13, 2008
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7NSQ
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7NSO
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7NSP
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7KSO
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![BU of 7kso by Molmil](/molmil-images/mine/7kso) | Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 | Descriptor: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | Authors: | Grau, D.J, Armache, K.J. | Deposit date: | 2020-11-23 | Release date: | 2021-02-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
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7KSR
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![BU of 7ksr by Molmil](/molmil-images/mine/7ksr) | PRC2:EZH1_A from a dimeric PRC2 bound to a nucleosome | Descriptor: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | Authors: | Grau, D.J, Armache, K.J. | Deposit date: | 2020-11-24 | Release date: | 2021-02-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
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3BR3
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4L5I
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4L5J
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6YUH
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![BU of 6yuh by Molmil](/molmil-images/mine/6yuh) | Crystal structure of SMYD3 with diperodon R enantiomer bound to allosteric site | Descriptor: | Diperodon, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... | Authors: | Cederfelt, D, Talibov, V.O, Dobritzsch, D, Danielson, U.H. | Deposit date: | 2020-04-27 | Release date: | 2021-01-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase. Chembiochem, 22, 2021
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3TPE
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![BU of 3tpe by Molmil](/molmil-images/mine/3tpe) | The phipa p3121 structure | Descriptor: | Serine/threonine-protein kinase HipA | Authors: | Schumacher, M.A, Link, T, Brennan, R.G. | Deposit date: | 2011-09-07 | Release date: | 2012-10-03 | Last modified: | 2018-03-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance. Cell Rep, 2, 2012
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6ZHC
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![BU of 6zhc by Molmil](/molmil-images/mine/6zhc) | PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL | Descriptor: | 1,2-ETHANEDIOL, 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]-5-[3-[4-[3-[2-[2-[2-[2-[2-[3-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]phenoxy]propyl]-1,3-thiazole-4-carboxylic acid, Bcl-2-like protein 1, ... | Authors: | Chung, C. | Deposit date: | 2020-06-22 | Release date: | 2020-08-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. Acs Chem.Biol., 15, 2020
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6YZ3
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![BU of 6yz3 by Molmil](/molmil-images/mine/6yz3) | PqsR (MvfR) in complex with antagonist 19 | Descriptor: | 1,2-ETHANEDIOL, 6-chloranyl-3-[(2-hexyl-2,3-dihydro-1,3-thiazol-4-yl)methyl]quinazolin-4-one, LysR family transcriptional regulator | Authors: | Richardson, W.K, Emsley, J. | Deposit date: | 2020-05-06 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. Eur.J.Med.Chem., 208, 2020
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6U48
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![BU of 6u48 by Molmil](/molmil-images/mine/6u48) | E. coli 50S with phazolicin (PHZ) bound in exit tunnel | Descriptor: | 23S rRNA, 50S ribosomal protein bL17, 50S ribosomal protein bL19, ... | Authors: | Watson, Z.L, Cate, J.H.D, Polikanov, Y.S, Severinov, K. | Deposit date: | 2019-08-23 | Release date: | 2019-09-18 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition. Nat Commun, 10, 2019
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6Z07
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![BU of 6z07 by Molmil](/molmil-images/mine/6z07) | PqsR (MvfR) in complex with antagonist 12 | Descriptor: | 3-[(2-~{tert}-butyl-1,3-thiazol-4-yl)methyl]-6-chloranyl-quinazolin-4-one, GLYCEROL, Transcriptional regulator MvfR | Authors: | Richardson, W.K, Emsley, J. | Deposit date: | 2020-05-07 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. Eur.J.Med.Chem., 208, 2020
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6Z5K
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![BU of 6z5k by Molmil](/molmil-images/mine/6z5k) | PqsR (MvfR) in complex with antagonist 18 | Descriptor: | 6-chloranyl-3-[(2-pentyl-2,3-dihydro-1,3-thiazol-4-yl)methyl]quinazolin-4-one, Transcriptional regulator MvfR | Authors: | Richardson, W.K, Emsley, J. | Deposit date: | 2020-05-26 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.201 Å) | Cite: | Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. Eur.J.Med.Chem., 208, 2020
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3TPB
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![BU of 3tpb by Molmil](/molmil-images/mine/3tpb) | Structure of HipA(S150A) | Descriptor: | CHLORIDE ION, PHOSPHATE ION, Serine/threonine-protein kinase HipA | Authors: | schumacher, M.A. | Deposit date: | 2011-09-07 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance. Cell Rep, 2, 2012
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6Z7O
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![BU of 6z7o by Molmil](/molmil-images/mine/6z7o) | Crystal structure of Thioredoxin T from Drosophila melanogaster | Descriptor: | Thioredoxin-T, ZINC ION | Authors: | Freier, R, Aragon, E, Baginski, B, Pluta, R, Martin-Malpartida, P, Torner, C, Gonzaez, C, Macias, M. | Deposit date: | 2020-05-31 | Release date: | 2020-10-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins. Iucrj, 8, 2021
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