Summary for 6ZHC
Entry DOI | 10.2210/pdb6zhc/pdb |
Descriptor | von Hippel-Lindau disease tumor suppressor, Elongin-B, Elongin-C, ... (9 entities in total) |
Functional Keywords | protac complex, targeted degradation, ubiquitin ligase, bifunctional ligand, e3 ligase, bcl-xl, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 70560.51 |
Authors | Chung, C. (deposition date: 2020-06-22, release date: 2020-08-05, Last modification date: 2024-01-24) |
Primary citation | Chung, C.W.,Dai, H.,Fernandez, E.,Tinworth, C.P.,Churcher, I.,Cryan, J.,Denyer, J.,Harling, J.D.,Konopacka, A.,Queisser, M.A.,Tame, C.J.,Watt, G.,Jiang, F.,Qian, D.,Benowitz, A.B. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. Acs Chem.Biol., 15:2316-2323, 2020 Cited by PubMed: 32697072DOI: 10.1021/acschembio.0c00266 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
Download full validation report