Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6ZHC

PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
BBB0000122biological_processnegative regulation of transcription by RNA polymerase II
BBB0000151cellular_componentubiquitin ligase complex
BBB0001222molecular_functiontranscription corepressor binding
BBB0005515molecular_functionprotein binding
BBB0005634cellular_componentnucleus
BBB0005654cellular_componentnucleoplasm
BBB0005737cellular_componentcytoplasm
BBB0005829cellular_componentcytosol
BBB0006351biological_processDNA-templated transcription
BBB0006367biological_processtranscription initiation at RNA polymerase II promoter
BBB0006368biological_processtranscription elongation by RNA polymerase II
BBB0016567biological_processprotein ubiquitination
BBB0030891cellular_componentVCB complex
BBB0031462cellular_componentCul2-RING ubiquitin ligase complex
BBB0031466cellular_componentCul5-RING ubiquitin ligase complex
BBB0031625molecular_functionubiquitin protein ligase binding
BBB0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
BBB0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
BBB0065003biological_processprotein-containing complex assembly
BBB0070449cellular_componentelongin complex
BBB0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
BBB0140958biological_processtarget-directed miRNA degradation
BBB1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
BBB2000104biological_processnegative regulation of DNA-templated DNA replication
CCC0006511biological_processubiquitin-dependent protein catabolic process
DDD0001836biological_processrelease of cytochrome c from mitochondria
DDD0005515molecular_functionprotein binding
DDD0005737cellular_componentcytoplasm
DDD0005739cellular_componentmitochondrion
DDD0005741cellular_componentmitochondrial outer membrane
DDD0005743cellular_componentmitochondrial inner membrane
DDD0005759cellular_componentmitochondrial matrix
DDD0005783cellular_componentendoplasmic reticulum
DDD0005813cellular_componentcentrosome
DDD0005829cellular_componentcytosol
DDD0006897biological_processendocytosis
DDD0006915biological_processapoptotic process
DDD0006950biological_processresponse to stress
DDD0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
DDD0008637biological_processapoptotic mitochondrial changes
DDD0015267molecular_functionchannel activity
DDD0016020cellular_componentmembrane
DDD0019901molecular_functionprotein kinase binding
DDD0030672cellular_componentsynaptic vesicle membrane
DDD0031410cellular_componentcytoplasmic vesicle
DDD0031965cellular_componentnuclear membrane
DDD0031966cellular_componentmitochondrial membrane
DDD0032465biological_processregulation of cytokinesis
DDD0034097biological_processresponse to cytokine
DDD0042802molecular_functionidentical protein binding
DDD0042981biological_processregulation of apoptotic process
DDD0043065biological_processpositive regulation of apoptotic process
DDD0043066biological_processnegative regulation of apoptotic process
DDD0046902biological_processregulation of mitochondrial membrane permeability
DDD0051434molecular_functionBH3 domain binding
DDD0051607biological_processdefense response to virus
DDD0051707biological_processresponse to other organism
DDD0051881biological_processregulation of mitochondrial membrane potential
DDD0055085biological_processtransmembrane transport
DDD0090201biological_processnegative regulation of release of cytochrome c from mitochondria
DDD0097136cellular_componentBcl-2 family protein complex
DDD0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
DDD1900118biological_processnegative regulation of execution phase of apoptosis
DDD1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
DDD1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
DDD1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
DDD1902531biological_processregulation of intracellular signal transduction
DDD1903077biological_processnegative regulation of protein localization to plasma membrane
DDD2001233biological_processregulation of apoptotic signaling pathway
DDD2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
DDD2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues19
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG
ChainResidueDetails
DDDLEU130-GLY148
site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
ChainResidueDetails
DDDTRP181-VAL192
site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
ChainResidueDetails
DDDVAL86-ARG100
site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
ChainResidueDetails
DDDSER4-TRP24
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues55
DetailsRegion: {"description":"Involved in binding to CCT complex"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues9
DetailsRegion: {"description":"Interaction with Elongin BC complex"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues65
DetailsDomain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues20
DetailsMotif: {"description":"BH4"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues14
DetailsMotif: {"description":"BH3"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues19
DetailsMotif: {"description":"BH1"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues15
DetailsMotif: {"description":"BH2"}
ChainResidueDetails

246333

PDB entries from 2025-12-17

PDB statisticsPDBj update infoContact PDBjnumon