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6ZHC

PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
BBB0001222molecular_functiontranscription corepressor binding
BBB0005515molecular_functionprotein binding
BBB0005634cellular_componentnucleus
BBB0005654cellular_componentnucleoplasm
BBB0005829cellular_componentcytosol
BBB0006367biological_processtranscription initiation at RNA polymerase II promoter
BBB0006368biological_processtranscription elongation by RNA polymerase II
BBB0016567biological_processprotein ubiquitination
BBB0030891cellular_componentVCB complex
BBB0031462cellular_componentCul2-RING ubiquitin ligase complex
BBB0031466cellular_componentCul5-RING ubiquitin ligase complex
BBB0031625molecular_functionubiquitin protein ligase binding
BBB0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
BBB0065003biological_processprotein-containing complex assembly
BBB0070449cellular_componentelongin complex
BBB0140958biological_processtarget-directed miRNA degradation
CCC0006511biological_processubiquitin-dependent protein catabolic process
DDD0001541biological_processovarian follicle development
DDD0001701biological_processin utero embryonic development
DDD0001836biological_processrelease of cytochrome c from mitochondria
DDD0005515molecular_functionprotein binding
DDD0005634cellular_componentnucleus
DDD0005737cellular_componentcytoplasm
DDD0005739cellular_componentmitochondrion
DDD0005741cellular_componentmitochondrial outer membrane
DDD0005743cellular_componentmitochondrial inner membrane
DDD0005759cellular_componentmitochondrial matrix
DDD0005783cellular_componentendoplasmic reticulum
DDD0005813cellular_componentcentrosome
DDD0005829cellular_componentcytosol
DDD0005856cellular_componentcytoskeleton
DDD0006897biological_processendocytosis
DDD0006915biological_processapoptotic process
DDD0006950biological_processresponse to stress
DDD0007005biological_processmitochondrion organization
DDD0007281biological_processgerm cell development
DDD0007283biological_processspermatogenesis
DDD0008584biological_processmale gonad development
DDD0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
DDD0008637biological_processapoptotic mitochondrial changes
DDD0009314biological_processresponse to radiation
DDD0009566biological_processfertilization
DDD0009615biological_processresponse to virus
DDD0016020cellular_componentmembrane
DDD0019901molecular_functionprotein kinase binding
DDD0030672cellular_componentsynaptic vesicle membrane
DDD0031410cellular_componentcytoplasmic vesicle
DDD0031965cellular_componentnuclear membrane
DDD0031966cellular_componentmitochondrial membrane
DDD0032465biological_processregulation of cytokinesis
DDD0032946biological_processpositive regulation of mononuclear cell proliferation
DDD0034097biological_processresponse to cytokine
DDD0035234biological_processectopic germ cell programmed cell death
DDD0040008biological_processregulation of growth
DDD0042802molecular_functionidentical protein binding
DDD0042981biological_processregulation of apoptotic process
DDD0043066biological_processnegative regulation of apoptotic process
DDD0043524biological_processnegative regulation of neuron apoptotic process
DDD0044565biological_processdendritic cell proliferation
DDD0045202cellular_componentsynapse
DDD0046898biological_processresponse to cycloheximide
DDD0046902biological_processregulation of mitochondrial membrane permeability
DDD0050673biological_processepithelial cell proliferation
DDD0051093biological_processnegative regulation of developmental process
DDD0051400molecular_functionBH domain binding
DDD0051402biological_processneuron apoptotic process
DDD0051434molecular_functionBH3 domain binding
DDD0051607biological_processdefense response to virus
DDD0051881biological_processregulation of mitochondrial membrane potential
DDD0071230biological_processcellular response to amino acid stimulus
DDD0071312biological_processcellular response to alkaloid
DDD0071480biological_processcellular response to gamma radiation
DDD0071839biological_processapoptotic process in bone marrow cell
DDD0090201biological_processnegative regulation of release of cytochrome c from mitochondria
DDD0097048biological_processdendritic cell apoptotic process
DDD0097136cellular_componentBcl-2 family protein complex
DDD0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
DDD0097284biological_processhepatocyte apoptotic process
DDD1900118biological_processnegative regulation of execution phase of apoptosis
DDD1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
DDD1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
DDD1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
DDD1903077biological_processnegative regulation of protein localization to plasma membrane
DDD2000242biological_processnegative regulation of reproductive process
DDD2000669biological_processnegative regulation of dendritic cell apoptotic process
DDD2001233biological_processregulation of apoptotic signaling pathway
DDD2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
DDD2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues19
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG
ChainResidueDetails
DDDLEU130-GLY148

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
ChainResidueDetails
DDDTRP181-VAL192

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
ChainResidueDetails
DDDVAL86-ARG100

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
ChainResidueDetails
DDDSER4-TRP24

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by caspase-1
ChainResidueDetails
DDDASP61

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:21840391
ChainResidueDetails
DDDSER49

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:19917720
ChainResidueDetails
DDDSER62

221051

PDB entries from 2024-06-12

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