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6ZHC

PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AAAvon Hippel-Lindau disease tumor suppressorpolymer15518012.51UniProt (P40337)
Pfam (PF01847)
Pfam (PF17211)
In PDB
Homo sapiens (Human)Protein G7,pVHL
2BBBElongin-Bpolymer10712088.71UniProt (Q15370)
Pfam (PF00240)
In PDB
Homo sapiens (Human)EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
3CCCElongin-Cpolymer9610843.41UniProt (Q15369)
Pfam (PF03931)
In PDB
Homo sapiens (Human)EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
4DDDBcl-2-like protein 1polymer22124879.41UniProt (Q07817)
Pfam (PF02180)
Pfam (PF00452)
In PDB
Homo sapiens (Human)Bcl2-L-1,Apoptosis regulator Bcl-X
5AAA2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]-5-[3-[4-[3-[2-[2-[2-[2-[2-[3-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]phenoxy]propyl]-1,3-thiazole-4-carboxylic acidnon-polymer1329.61Chemie (QL8)
6CCC, AAA, DDD, BBB1,2-ETHANEDIOLnon-polymer62.117Chemie (EDO)
7CCC, AAA, DDDGLYCEROLnon-polymer92.19Chemie (GOL)
8CCC, AAA, DDD, BBBIODIDE IONnon-polymer126.912Chemie (IOD)
9waterwater18.0460Chemie (HOH)
Sequence modifications
DDD: 1 - 209 (UniProt: Q07817)
PDBExternal DatabaseDetails
Met -3-initiating methionine
Ser -2-expression tag
Met -1-expression tag
Ala 0-expression tag
Leu 210-expression tag
Glu 211-expression tag
His 212-expression tag
His 213-expression tag
His 214-expression tag
His 215-expression tag
His 216-expression tag
His 217-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight65824.1
Non-Polymers*Number of molecules39
Total formula weight4736.5
All*Total formula weight70560.5
*Water molecules are not included.

221051

PDB entries from 2024-06-12

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