4L5J

Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition

Summary for 4L5J

Entry DOI	10.2210/pdb4l5j/pdb
Related	4L4Y 4L4Z 4L50 4L51 4L5I
Descriptor	Transcriptional regulator LsrR, 5-O-phosphono-alpha-D-ribofuranose (3 entities in total)
Functional Keywords	dna transcriptional regulator, phospho-ai-2 binding, dna binding, transcription regulator, sorc/deor family, helix-turn-helix domain
Biological source	Escherichia coli
Total number of polymer chains	4
Total formula weight	136587.80
Authors	Ryu, K.S.,Ha, J.H.,Eo, Y. (deposition date: 2013-06-11, release date: 2013-11-06, Last modification date: 2024-02-28)
Primary citation	Ha, J.H.,Eo, Y.,Grishaev, A.,Guo, M.,Smith, J.A.,Sintim, H.O.,Kim, E.H.,Cheong, H.K.,Bentley, W.E.,Ryu, K.S. Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition. J.Am.Chem.Soc., 135:15526-15535, 2013 Cited by PubMed: 24047255 DOI: 10.1021/ja407068v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation