3I89
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![BU of 3i89 by Molmil](/molmil-images/mine/3i89) | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR22 | Descriptor: | DNA damage-binding protein 1, WD repeat-containing protein 22 | Authors: | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | Deposit date: | 2009-07-09 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
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5IXS
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![BU of 5ixs by Molmil](/molmil-images/mine/5ixs) | Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one | Descriptor: | (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one, 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | Authors: | Ultsch, M, Eigenbrot, C. | Deposit date: | 2016-03-23 | Release date: | 2016-09-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Med.Chem.Lett., 7, 2016
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5IVE
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![BU of 5ive by Molmil](/molmil-images/mine/5ive) | Linked KDM5A Jmj Domain Bound to the Inhibitor N8 ( 5-methyl-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile) | Descriptor: | 5-methyl-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile, Lysine-specific demethylase 5A, MANGANESE (II) ION | Authors: | Horton, J.R, Cheng, X. | Deposit date: | 2016-03-20 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.783 Å) | Cite: | Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23, 2016
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8AXZ
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![BU of 8axz by Molmil](/molmil-images/mine/8axz) | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with S-adenosylmethionine, adenosin and diphosphono-aminophosphonic acid. | Descriptor: | (DIPHOSPHONO)AMINOPHOSPHONIC ACID, ADENOSINE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Nawrotek, A, Vuillard, L, Miallau, L. | Deposit date: | 2022-09-01 | Release date: | 2022-10-05 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.154 Å) | Cite: | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with S-adenosylmethionine, adenosin and diphosphono-aminophosphonic acid. To Be Published
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3IJ1
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![BU of 3ij1 by Molmil](/molmil-images/mine/3ij1) | Crystal structure of Eed in complex with a trimethylated histone H4K20 peptide | Descriptor: | Histone H4K20 peptide, Polycomb protein EED | Authors: | Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J. | Deposit date: | 2009-08-03 | Release date: | 2009-09-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 461, 2009
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3I8C
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![BU of 3i8c by Molmil](/molmil-images/mine/3i8c) | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR21A | Descriptor: | DNA damage-binding protein 1, WD repeat-containing protein 21A | Authors: | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | Deposit date: | 2009-07-09 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
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8AJM
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![BU of 8ajm by Molmil](/molmil-images/mine/8ajm) | Structure of human DDB1-DCAF12 in complex with the C-terminus of CCT5 | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2022-07-28 | Release date: | 2022-11-09 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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8AJN
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![BU of 8ajn by Molmil](/molmil-images/mine/8ajn) | Structure of the human DDB1-DCAF12 complex | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1 | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2022-07-28 | Release date: | 2022-11-09 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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8AJO
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![BU of 8ajo by Molmil](/molmil-images/mine/8ajo) | Negative-stain electron microscopy structure of DDB1-DCAF12-CCT5 | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2022-07-28 | Release date: | 2022-11-09 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (30.6 Å) | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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3KFC
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![BU of 3kfc by Molmil](/molmil-images/mine/3kfc) | Complex Structure of LXR with an agonist | Descriptor: | 4-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)quinoline, Oxysterols receptor LXR-beta | Authors: | Olland, A, Bernotas, R.C, Unwalla, R. | Deposit date: | 2009-10-27 | Release date: | 2009-12-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists. Bioorg.Med.Chem.Lett., 20, 2010
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3KB7
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![BU of 3kb7 by Molmil](/molmil-images/mine/3kb7) | Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor | Descriptor: | 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide, L(+)-TARTARIC ACID, Serine/threonine-protein kinase PLK1, ... | Authors: | Bossi, R.T, Bertrand, J.A. | Deposit date: | 2009-10-20 | Release date: | 2010-05-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors J.Med.Chem., 53, 2010
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5JLJ
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![BU of 5jlj by Molmil](/molmil-images/mine/5jlj) | Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1 | Descriptor: | (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, CHLORIDE ION, Exportin-1, ... | Authors: | Fung, H.Y, Chook, Y.M. | Deposit date: | 2016-04-27 | Release date: | 2016-06-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia, 30, 2016
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3JT0
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![BU of 3jt0 by Molmil](/molmil-images/mine/3jt0) | Crystal Structure of the C-terminal fragment (426-558) Lamin-B1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR5546A | Descriptor: | Lamin-B1 | Authors: | Kuzin, A, Abashidze, M, Seetharaman, J, Sahdev, S, Xiao, R, Ciccosanti, C, Belote, R.L, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-09-11 | Release date: | 2009-09-22 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (2.392 Å) | Cite: | Northeast Structural Genomics Consortium Target HR5546A To be Published
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5K0Y
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![BU of 5k0y by Molmil](/molmil-images/mine/5k0y) | m48S late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eIF2 ternary complex and eIF3 i and g subunits relocated to the intersubunit face | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S12, 40S ribosomal protein S21, ... | Authors: | Simonetti, A, Brito Querido, J, Myasnikov, A.G, Mancera-Martinez, E, Renaud, A, Kuhn, L, Hashem, Y. | Deposit date: | 2016-05-17 | Release date: | 2016-07-13 | Last modified: | 2018-04-18 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition. Mol.Cell, 63, 2016
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3JSX
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![BU of 3jsx by Molmil](/molmil-images/mine/3jsx) | X-ray Crystal structure of NAD(P)H: Quinone Oxidoreductase-1 (NQO1) bound to the coumarin-based inhibitor AS1 | Descriptor: | 4-hydroxy-6,7-dimethyl-3-(naphthalen-1-ylmethyl)-2H-chromen-2-one, FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H dehydrogenase [quinone] 1 | Authors: | Dunstan, M.S, Levy, C, Leys, D. | Deposit date: | 2009-09-11 | Release date: | 2010-01-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J.Med.Chem., 52, 2009
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3J7P
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![BU of 3j7p by Molmil](/molmil-images/mine/3j7p) | Structure of the 80S mammalian ribosome bound to eEF2 | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | Authors: | Voorhees, R.M, Fernandez, I.S, Scheres, S.H.W, Hegde, R.S. | Deposit date: | 2014-08-01 | Release date: | 2014-09-03 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution. Cell(Cambridge,Mass.), 157, 2014
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3K2J
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![BU of 3k2j by Molmil](/molmil-images/mine/3k2j) | Crystal Structure of the 3rd Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) | Descriptor: | CHLORIDE ION, Protein polybromo-1, SULFATE ION | Authors: | Filippakopoulos, P, Picaud, S, Keates, T, Chaikuad, A, Pike, A.C.W, Krojer, T, Sethi, R, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-30 | Release date: | 2009-10-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of the 3rd Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) To be Published
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5JY3
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![BU of 5jy3 by Molmil](/molmil-images/mine/5jy3) | |
8ASC
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![BU of 8asc by Molmil](/molmil-images/mine/8asc) | Ku70/80 binds to the Ku-binding motif of PAXX | Descriptor: | DNA (5'-D(P*CP*GP*GP*AP*TP*CP*GP*AP*GP*GP*GP*CP*CP*CP*GP*AP*TP*AP*T)-3'), DNA (5'-D(P*GP*GP*GP*CP*CP*CP*TP*CP*GP*AP*TP*CP*CP*G)-3'), Protein PAXX, ... | Authors: | Seif El Dahan, M, Ropars, V, Charbonnier, J.B. | Deposit date: | 2022-08-19 | Release date: | 2023-06-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023
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3K0M
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![BU of 3k0m by Molmil](/molmil-images/mine/3k0m) | Cryogenic structure of CypA | Descriptor: | Cyclophilin A | Authors: | Fraser, J.S, Alber, T. | Deposit date: | 2009-09-24 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Hidden alternative structures of proline isomerase essential for catalysis. Nature, 462, 2009
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3K0R
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![BU of 3k0r by Molmil](/molmil-images/mine/3k0r) | |
8AEL
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![BU of 8ael by Molmil](/molmil-images/mine/8ael) | SYNJ2BP complex with a synthetic Vangl2 peptide (3mer). | Descriptor: | CALCIUM ION, GLY-GLY-GLY-THR-SER-VAL, GLYCEROL, ... | Authors: | Carrasco, K, Cousido Siah, A, Gogl, G, Betzi, S, McEwen, A, Kostmann, C, Trave, G. | Deposit date: | 2022-07-13 | Release date: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | SYNJ2BP PDZ domain in complex with a synthetic Vangl2 peptide. To Be Published
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3K6P
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![BU of 3k6p by Molmil](/molmil-images/mine/3k6p) | Estrogen Related Receptor alpha in Complex with an Ether Based Ligand | Descriptor: | 4-(4-{[(5R)-2,4-dioxo-1,3-thiazolidin-5-yl]methyl}-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile, Steroid hormone receptor ERR1 | Authors: | Abad, M.C, Patch, R.J. | Deposit date: | 2009-10-09 | Release date: | 2010-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.996 Å) | Cite: | Development of Diaryl Ether based ligands for Estrogen Related Receptor alpha as Potential Anti-Diabetic Agents. To be Published
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5KDH
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![BU of 5kdh by Molmil](/molmil-images/mine/5kdh) | CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A DIHYDROPYRIDOPYRIMIDINE SCAFFOLD INHIBITOR | Descriptor: | (5~{S})-1-ethyl-5-(4-methylphenyl)-8,9-dihydro-5~{H}-furo[3,4]pyrido[3,5-~{b}]pyrimidine-2,4,6-trione, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ... | Authors: | Zhu, J.-Y, Schonbrunn, E. | Deposit date: | 2016-06-08 | Release date: | 2017-08-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen. J. Med. Chem., 60, 2017
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8B3F
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![BU of 8b3f by Molmil](/molmil-images/mine/8b3f) | Pol II-CSB-CSA-DDB1-ELOF1 | Descriptor: | DNA damage-binding protein 1, DNA excision repair protein ERCC-6, DNA excision repair protein ERCC-8, ... | Authors: | Kokic, G, Cramer, P. | Deposit date: | 2022-09-16 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Pol II-CSB-CSA-DDB1-ELOF1 structure. To Be Published
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