5JY3

CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH BMS-852927

Summary for 5JY3

Entry DOI	10.2210/pdb5jy3/pdb
Descriptor	Oxysterols receptor LXR-beta, 2-[2-[2-[2,6-bis(chloranyl)phenyl]propan-2-yl]-1-[2-fluoranyl-4-[3-fluoranyl-4-(hydroxymethyl)-5-methylsulfonyl-phenyl] phenyl]imidazol-4-yl]propan-2-ol, 1,4-BUTANEDIOL, ... (4 entities in total)
Functional Keywords	nhr, nr1h2, lxr-b, lxrb, unr, ner-i, rip15, ner, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P55055
Total number of polymer chains	4
Total formula weight	124789.70
Authors	Muckelbauer, J.K. (deposition date: 2016-05-13, release date: 2016-11-02, Last modification date: 2024-03-06)
Primary citation	Kick, E.K.,Busch, B.B.,Martin, R.,Stevens, W.C.,Bollu, V.,Xie, Y.,Boren, B.C.,Nyman, M.C.,Nanao, M.H.,Nguyen, L.,Plonowski, A.,Schulman, I.G.,Yan, G.,Zhang, H.,Hou, X.,Valente, M.N.,Narayanan, R.,Behnia, K.,Rodrigues, A.D.,Brock, B.,Smalley, J.,Cantor, G.H.,Lupisella, J.,Sleph, P.,Grimm, D.,Ostrowski, J.,Wexler, R.R.,Kirchgessner, T.,Mohan, R. Discovery of Highly Potent Liver X Receptor beta Agonists. ACS Med Chem Lett, 7:1207-1212, 2016 Cited by PubMed: 27994765 DOI: 10.1021/acsmedchemlett.6b00234 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation