5JY3

CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH BMS-852927

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Oxysterols receptor LXR-beta	polymer	264	30542.9	4	UniProt (P55055) Pfam (PF00104) In PDB	Homo sapiens (Human)	Liver X receptor beta,Nuclear receptor NER,Nuclear receptor subfamily 1 group H member 2,Ubiquitously-expressed nuclear receptor
2	A, B, C, D	2-[2-[2-[2,6-bis(chloranyl)phenyl]propan-2-yl]-1-[2-fluoranyl-4-[3-fluoranyl-4-(hydroxymethyl)-5-methylsulfonyl-phenyl] phenyl]imidazol-4-yl]propan-2-ol	non-polymer		609.5	4	Chemie (6OX)
3	B, D	1,4-BUTANEDIOL	non-polymer		90.1	2	Chemie (BU1)
4		water	water		18.0	150	Chemie (HOH)

Sequence modifications

A, B, C, D: 214 - 461 (UniProt: P55055)

PDB	External Database	Details
Met 198	-	initiating methionine
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
Gly 205	-	expression tag
Glu 206	-	expression tag
Asn 207	-	expression tag
Leu 208	-	expression tag
Tyr 209	-	expression tag
Phe 210	-	expression tag
Gln 211	-	expression tag
Gly 212	-	expression tag
Ser 213	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	122171.4
Non-Polymers*	Number of molecules	6
	Total formula weight	2618.3
All*	Total formula weight	124789.7

*Water molecules are not included.