5IVE
Linked KDM5A Jmj Domain Bound to the Inhibitor N8 ( 5-methyl-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile)
Summary for 5IVE
Entry DOI | 10.2210/pdb5ive/pdb |
Related | 5ISL 5IVB 5IVC 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF |
Descriptor | Lysine-specific demethylase 5A, 5-methyl-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile, MANGANESE (II) ION, ... (4 entities in total) |
Functional Keywords | demethylase inhibition, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus, nucleolus : P29375 |
Total number of polymer chains | 1 |
Total formula weight | 38216.01 |
Authors | Horton, J.R.,Cheng, X. (deposition date: 2016-03-20, release date: 2016-07-27, Last modification date: 2023-09-27) |
Primary citation | Horton, J.R.,Liu, X.,Gale, M.,Wu, L.,Shanks, J.R.,Zhang, X.,Webber, P.J.,Bell, J.S.,Kales, S.C.,Mott, B.T.,Rai, G.,Jansen, D.J.,Henderson, M.J.,Urban, D.J.,Hall, M.D.,Simeonov, A.,Maloney, D.J.,Johns, M.A.,Fu, H.,Jadhav, A.,Vertino, P.M.,Yan, Q.,Cheng, X. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23:769-781, 2016 Cited by PubMed: 27427228DOI: 10.1016/j.chembiol.2016.06.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.783 Å) |
Structure validation
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