7Z29
| Cryo-EM structure of NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with nevirapine | Descriptor: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, DNA (38-MER), Reverse transcriptase/ribonuclease H, ... | Authors: | Singh, A.K, Das, K. | Deposit date: | 2022-02-26 | Release date: | 2022-07-20 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine. Proc.Natl.Acad.Sci.USA, 119, 2022
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7Z03
| Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and extended dsDNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (39-MER), MAGNESIUM ION, ... | Authors: | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | Deposit date: | 2022-02-21 | Release date: | 2022-08-17 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50. Mol.Cell, 82, 2022
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7YZO
| Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and dsDNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (31-MER), MAGNESIUM ION, ... | Authors: | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | Deposit date: | 2022-02-21 | Release date: | 2022-08-17 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50. Mol.Cell, 82, 2022
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2MHP
| Solution structure of the major factor VIII binding region on von Willebrand factor | Descriptor: | von Willebrand factor | Authors: | Shiltagh, N, Kirkpatrick, J, Cabrita, L.D, McKinnon, T.A.J, Thalassinos, K, Tuddenham, E.G.D, Hansen, D.F. | Deposit date: | 2013-12-02 | Release date: | 2014-05-14 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution structure of the major factor VIII binding region on von Willebrand factor. Blood, 123, 2014
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2MHQ
| Solution structure of the major factor VIII binding region on von Willebrand factor | Descriptor: | von Willebrand factor | Authors: | Shiltagh, N, Kirkpatrick, J, Cabrita, L.D, McKinnon, T.A.J, Thalassinos, K, Tuddenham, E.G.D, Hansen, D.F. | Deposit date: | 2013-12-02 | Release date: | 2014-05-14 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution structure of the major factor VIII binding region on von Willebrand factor. Blood, 123, 2014
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4QD2
| Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex | Descriptor: | CALCIUM ION, Cadherin-1, Hemagglutinin component HA17, ... | Authors: | Lee, K, Zhong, X, Gu, S, Kruel, A, Dorner, M.B, Perry, K, Rummel, A, Dong, M, Jin, R. | Deposit date: | 2014-05-13 | Release date: | 2014-06-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science, 344, 2014
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8A9T
| Tubulin-[1,2]oxazoloisoindole-1 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Prota, A.E, Abel, A.-C, Steinmetz, M.O, Barraja, P, Montalbano, A, Spano, V. | Deposit date: | 2022-06-29 | Release date: | 2022-11-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.304 Å) | Cite: | Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. Eur.J.Med.Chem., 243, 2022
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7UW1
| A. baumannii 70S ribosome-Streptothricin-D complex | Descriptor: | 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Morgan, C.E, Yu, E.W. | Deposit date: | 2022-05-02 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.21 Å) | Cite: | Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. Plos Biol., 21, 2023
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7UVY
| A. baumannii ribosome-Streptothricin-D complex: 70S with P-site tRNA | Descriptor: | 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Morgan, C.E, Yu, E.W. | Deposit date: | 2022-05-02 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.39 Å) | Cite: | Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. Plos Biol., 21, 2023
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7UVV
| A. baumannii ribosome-Streptothricin-F complex: 70S with P-site tRNA | Descriptor: | 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Morgan, C.E, Yu, E.W. | Deposit date: | 2022-05-02 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. Plos Biol., 21, 2023
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7UVX
| A. baumannii 70S ribosome-Streptothricin-F complex | Descriptor: | 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Morgan, C.E, Yu, E.W. | Deposit date: | 2022-05-02 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.35 Å) | Cite: | Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. Plos Biol., 21, 2023
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6J31
| Crystal Structure Analysis of the Glycotransferase of kitacinnamycin | Descriptor: | (2E,2'E)-3,3'-(1,2-phenylene)di(prop-2-enoic acid), DBB-DSG-VAL-MEA-VAL-GLY-GLY-DVA-DLE, kcn28 | Authors: | Shi, J, Liu, C.L, Zhang, B, Guo, W.J, Zhu, J.P, Xu, X, Xu, Q, Jiao, R.H, Tan, R.X, Ge, H.M. | Deposit date: | 2019-01-03 | Release date: | 2020-01-15 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.244 Å) | Cite: | Genome mining and biosynthesis of kitacinnamycins as a STING activator. Chem Sci, 10, 2019
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6PXQ
| Crystal structure of human thrombin mutant D194A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin heavy chain, Thrombin light chain | Authors: | Stojanovski, B, Chen, Z, Koester, S.K, Pelc, L.A, Di Cera, E. | Deposit date: | 2019-07-26 | Release date: | 2019-12-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Role of the I16-D194 ionic interaction in the trypsin fold. Sci Rep, 9, 2019
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6Q9K
| Crystal structure of reduced Aquifex aeolicus NADH-quinone oxidoreductase subunits NuoE and NuoF S96M bound to NADH | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | Authors: | Wohlwend, D, Gerhardt, S, Gnandt, E, Friedrich, T. | Deposit date: | 2018-12-18 | Release date: | 2019-06-26 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I. Nat Commun, 10, 2019
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5O4W
| Protein structure determination by electron diffraction using a single three-dimensional nanocrystal | Descriptor: | Lysozyme C | Authors: | Clabbers, M.T.B, van Genderen, E, Wan, W, Wiegers, E.L, Gruene, T, Abrahams, J.P. | Deposit date: | 2017-05-31 | Release date: | 2017-08-23 | Last modified: | 2024-01-17 | Method: | ELECTRON CRYSTALLOGRAPHY (2.11 Å) | Cite: | Protein structure determination by electron diffraction using a single three-dimensional nanocrystal. Acta Crystallogr D Struct Biol, 73, 2017
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6Z5S
| RC-LH1(14)-W complex from Rhodopseudomonas palustris | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, (6~{R},10~{S},14~{R},19~{R},23~{S},24~{E},27~{S},28~{E})-2,6,10,14,19,23,27,31-octamethyldotriaconta-24,28-dien-2-ol, ... | Authors: | Swainsbury, D.J.K, Qian, P, Hitchcock, A, Hunter, C.N. | Deposit date: | 2020-05-27 | Release date: | 2021-01-13 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Structures of Rhodopseudomonas palustris RC-LH1 complexes with open or closed quinone channels. Sci Adv, 7, 2021
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8EEE
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1ANJ
| ALKALINE PHOSPHATASE (K328H) | Descriptor: | ALKALINE PHOSPHATASE, PHOSPHATE ION, ZINC ION | Authors: | Murphy, J.E, Tibbitts, T.T, Kantrowitz, E.R. | Deposit date: | 1995-09-06 | Release date: | 1996-01-29 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases. J.Mol.Biol., 253, 1995
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1ANI
| ALKALINE PHOSPHATASE (D153H, K328H) | Descriptor: | ALKALINE PHOSPHATASE, PHOSPHATE ION, ZINC ION | Authors: | Murphy, J.E, Tibbitts, T.T, Kantrowitz, E.R. | Deposit date: | 1995-09-06 | Release date: | 1996-01-29 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases. J.Mol.Biol., 253, 1995
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2NU6
| C123aA Mutant of E. coli Succinyl-CoA Synthetase | Descriptor: | COENZYME A, SULFATE ION, Succinyl-CoA ligase [ADP-forming] subunit alpha, ... | Authors: | Fraser, M.E. | Deposit date: | 2006-11-08 | Release date: | 2007-07-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Participation of Cys 123alpha of Escherichia coli Succinyl-CoA Synthetase in Catalysis ACTA CRYSTALLOGR.,SECT.D, 63, 2007
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5F15
| Crystal Structure of ArnT from Cupriavidus metallidurans bound to Undecaprenyl phosphate | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-amino-4-deoxy-L-arabinose (L-Ara4N) transferase, CHLORIDE ION, ... | Authors: | Petrou, V.I, Clarke, O.B, Tomasek, D, Banerjee, S, Rajashankar, K.R, Mancia, F, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2015-11-30 | Release date: | 2016-02-17 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation. Science, 351, 2016
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7QCS
| PALS1/MPP5 PDZ domain in complex with SARS-CoV-2_E PBM peptide | Descriptor: | Envelope small membrane protein, Protein PALS1 | Authors: | Zhu, Y, Alvarez, F, Haouz, A, Mechaly, A, Caillet-Saguy, C. | Deposit date: | 2021-11-25 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.804 Å) | Cite: | Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins. Front Microbiol, 13, 2022
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5W75
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8PNT
| Structure of the human nuclear cap-binding complex bound to PHAX and m7G-capped RNA | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ... | Authors: | Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J. | Deposit date: | 2023-07-01 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex. Cell Rep, 43, 2024
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6OHL
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