8A9T

Tubulin-[1,2]oxazoloisoindole-1 complex

Summary for 8A9T

• Entry DOI: 10.2210/pdb8a9t/pdb
• Descriptor: Tubulin alpha-1B chain, ethyl 13-[(3,5-dimethoxyphenyl)methyl]-3-oxa-4,13-diazatricyclo[8.3.0.0^{2,6}]trideca-1(10),2(6),4,11-tetraene-12-carboxylate, IMIDAZOLE, ... (13 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265027.66

Authors

Prota, A.E.,Abel, A.-C.,Steinmetz, M.O.,Barraja, P.,Montalbano, A.,Spano, V. (deposition date: 2022-06-29, release date: 2022-11-09, Last modification date: 2024-01-31)

• Primary citation: Barreca, M.,Spano, V.,Rocca, R.,Bivacqua, R.,Abel, A.C.,Maruca, A.,Montalbano, A.,Raimondi, M.V.,Tarantelli, C.,Gaudio, E.,Cascione, L.,Rinaldi, A.,Bai, R.,Steinmetz, M.O.,Prota, A.E.,Alcaro, S.,Hamel, E.,Bertoni, F.,Barraja, P.; Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas.; Eur.J.Med.Chem., 243:114744-114744, 2022; PubMed: 36242921; DOI: 10.1016/j.ejmech.2022.114744

Experimental method

X-RAY DIFFRACTION (2.304 Å)