4QD2

Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex

Summary for 4QD2

DescriptorHemagglutinin component HA33, Hemagglutinin component HA17, Hemagglutinin component HA70, ... (6 entities in total)
Functional Keywordsoral toxicity, botulinum neurotoxin, e-cadherin, ha70, ha17, ha33, cell adhesion
Biological sourceClostridium botulinum
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Cellular locationCell junction P09803
Total number of polymer chains10
Total molecular weight274921.05
Authors
Lee, K.,Zhong, X.,Gu, S.,Kruel, A.,Dorner, M.B.,Perry, K.,Rummel, A.,Dong, M.,Jin, R. (deposition date: 2014-05-13, release date: 2014-06-25, Last modification date: 2014-07-02)
Primary citation
Lee, K.,Zhong, X.,Gu, S.,Kruel, A.M.,Dorner, M.B.,Perry, K.,Rummel, A.,Dong, M.,Jin, R.
Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.
Science, 344:1405-1410, 2014
PubMed: 24948737 (PDB entries with the same primary citation)
DOI: 10.1126/science.1253823
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.239304.6%7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4qd2
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Molmil generated image of 4qd2
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Molmil generated image of 4qd2
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More Biological unit images

Molmil generated image of 4qd2
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Molmil generated image of 4qd2
rotated about x axis by 90°
Molmil generated image of 4qd2
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4qd2.pdb2.gz [404.26 KB])
Coordinate files for Biological unit (4qd2.pdb1.gz [403.92 KB])