4QD2
Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | D, C, I, H | Hemagglutinin component HA33 | polymer | 296 | 34081.7 | 4 | UniProt (A5HZZ6) Pfam (PF14200) In PDB | Clostridium botulinum | Hemagglutinin component of the neurotoxin complex |
2 | B, G | Hemagglutinin component HA17 | polymer | 147 | 17069.2 | 2 | UniProt (A5HZZ5) Pfam (PF05588) In PDB | Clostridium botulinum | Hemagglutinin component of the neurotoxin complex |
3 | A, F | Hemagglutinin component HA70 | polymer | 254 | 28846.9 | 2 | UniProt (A5HZZ4) Pfam (PF17993) In PDB | Clostridium botulinum | Hemagglutinin component of the neurotoxin complex |
4 | E, J | Cadherin-1 | polymer | 213 | 23260.9 | 2 | UniProt (P09803) Pfam (PF00028) In PDB | Mus musculus (mouse) | ARC-1, Epithelial cadherin, E-cadherin, Uvomorulin, E-Cad/CTF1, E-Cad/CTF2, E-Cad/CTF3 |
5 | E, J | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
6 | water | water | 18.0 | 402 | Chemie (HOH) |
Sequence modifications
D, C, I, H: 2 - 293 (UniProt: A5HZZ6)
B, G: 2 - 146 (UniProt: A5HZZ5)
A, F: 378 - 626 (UniProt: A5HZZ4)
PDB | External Database | Details |
---|---|---|
Pro 294 | - | expression tag |
Gly 295 | - | expression tag |
Ser 296 | - | expression tag |
Ala 297 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Pro 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 373 | - | expression tag |
Pro 374 | - | expression tag |
Leu 375 | - | expression tag |
Gly 376 | - | expression tag |
Ser 377 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 274680.6 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 240.5 | |
All* | Total formula weight | 274921.1 |