3O4M
| Crystal structure of porcine pancreatic phospholipase A2 in complex with 1,2-dihydroxybenzene | Descriptor: | CALCIUM ION, CATECHOL, Phospholipase A2, ... | Authors: | Dileep, K.V, Tintu, I, Karthe, P, Mandal, P.K, Haridas, M, Sadasivan, C. | Deposit date: | 2010-07-27 | Release date: | 2010-08-25 | Last modified: | 2011-11-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Binding to PLA(2) may contribute to the anti-inflammatory activity of catechol Chem.Biol.Drug Des., 2011
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7UY1
| HUMAN PRMT5:MEP50 COMPLEX WITH MTA and Fragment 5 Bound | Descriptor: | 1,2-ETHANEDIOL, 3-methyl-1,5-naphthyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... | Authors: | Gunn, R.J. | Deposit date: | 2022-05-06 | Release date: | 2022-10-05 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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1FV5
| SOLUTION STRUCTURE OF THE FIRST ZINC FINGER FROM THE DROSOPHILA U-SHAPED TRANSCRIPTION FACTOR | Descriptor: | FIRST ZINC FINGER OF U-SHAPED, ZINC ION | Authors: | Liew, C.K, Kowalski, K, Fox, A.H, Newton, A, Sharpe, B.K, Crossley, M, Mackay, J.P. | Deposit date: | 2000-09-18 | Release date: | 2000-10-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structures of two CCHC zinc fingers from the FOG family protein U-shaped that mediate protein-protein interactions. Structure Fold.Des., 8, 2000
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4IMZ
| Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus | Descriptor: | Genome polyprotein, SODIUM ION, THIOCYANATE ION, ... | Authors: | Prasad, B.V.V, Muhaxhiri, Z, Deng, L, Shanker, S, Sankaran, B, Estes, M.K, Palzkill, T, Song, Y. | Deposit date: | 2013-01-03 | Release date: | 2013-02-20 | Last modified: | 2013-04-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis of substrate specificity and protease inhibition in norwalk virus. J.Virol., 87, 2013
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5OL6
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8PK6
| INTS13 complex with ZNF655 | Descriptor: | Integrator complex subunit 13, Zinc finger protein 655 | Authors: | Sabath, K, Jonas, S. | Deposit date: | 2023-06-25 | Release date: | 2024-07-03 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Basis of gene-specific transcription regulation by the Integrator complex. Mol.Cell, 84, 2024
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3QFB
| Crystal structure of the human thioredoxin reductase-thioredoxin complex | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... | Authors: | Fritz-Wolf, K, Kehr, S, Stumpf, M, Rahlfs, S, Becker, K. | Deposit date: | 2011-01-21 | Release date: | 2011-07-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the human thioredoxin reductase-thioredoxin complex Nat Commun, 2, 2011
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1EER
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1FU9
| SOLUTION STRUCTURE OF THE NINTH ZINC-FINGER DOMAIN OF THE U-SHAPED TRANSCRIPTION FACTOR | Descriptor: | U-SHAPED TRANSCRIPTIONAL COFACTOR, ZINC ION | Authors: | Liew, C.K, Kowalski, K, Fox, A.H, Newton, A, Sharpe, B.K, Crossley, M, Mackay, J.P. | Deposit date: | 2000-09-14 | Release date: | 2000-10-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structures of two CCHC zinc fingers from the FOG family protein U-shaped that mediate protein-protein interactions. Structure Fold.Des., 8, 2000
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6JYT
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6K1S
| Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors | Descriptor: | 1,2-ETHANEDIOL, 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal, DIMETHYL SULFOXIDE, ... | Authors: | Tong, S, Lin, H. | Deposit date: | 2019-05-12 | Release date: | 2019-06-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors. Acs Med.Chem.Lett., 10, 2019
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1TVO
| The structure of ERK2 in complex with a small molecule inhibitor | Descriptor: | 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, Mitogen-activated protein kinase 1 | Authors: | Kinoshita, T. | Deposit date: | 2004-06-30 | Release date: | 2005-09-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex Biochem.Biophys.Res.Commun., 336, 2005
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1HZI
| INTERLEUKIN-4 MUTANT E9A | Descriptor: | INTERLEUKIN-4, SULFATE ION | Authors: | Hulsmeyer, M, Scheufler, C, Dreyer, M.K. | Deposit date: | 2001-01-25 | Release date: | 2001-08-29 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation. Acta Crystallogr.,Sect.D, 57, 2001
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1HIK
| INTERLEUKIN-4 (WILD-TYPE) | Descriptor: | INTERLEUKIN-4 | Authors: | Mueller, T, Buehner, M. | Deposit date: | 1995-06-01 | Release date: | 1996-01-29 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models. J.Mol.Biol., 247, 1995
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7C9Q
| Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with Mg2+ and AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, MAGNESIUM ION | Authors: | Huang, Y, Li, R, Wan, J. | Deposit date: | 2020-06-07 | Release date: | 2021-06-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.878 Å) | Cite: | Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with Mg2+ and AMP To Be Published
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5FN3
| Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | Descriptor: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | Authors: | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | Deposit date: | 2015-11-10 | Release date: | 2015-12-16 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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5FN2
| Cryo-EM structure of gamma secretase in complex with a drug DAPT | Descriptor: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | Authors: | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | Deposit date: | 2015-11-10 | Release date: | 2015-12-16 | Last modified: | 2019-09-04 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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8JZZ
| Structure of human C5a-desArg bound human C5aR1 in complex with Go | Descriptor: | Antibody fragment ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... | Authors: | Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. | Deposit date: | 2023-07-06 | Release date: | 2023-10-18 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
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5FN5
| Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | Descriptor: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | Authors: | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | Deposit date: | 2015-11-10 | Release date: | 2015-12-16 | Last modified: | 2019-09-11 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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2RGN
| Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | Authors: | Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. | Deposit date: | 2007-10-04 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science, 318, 2007
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8BNT
| The DH domain of ARHGEF2 bound to RhoA | Descriptor: | DIMETHYL SULFOXIDE, FORMIC ACID, Rho guanine nucleotide exchange factor 2, ... | Authors: | Bradshaw, W.J, Katis, V.L, Grosjean, H, Bountra, C, von Delft, F, Brennan, P.E. | Deposit date: | 2022-11-25 | Release date: | 2022-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The DH domain of ARHGEF2 bound to RhoA To Be Published
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1ITM
| ANALYSIS OF THE SOLUTION STRUCTURE OF HUMAN INTERLEUKIN 4 DETERMINED BY HETERONUCLEAR THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE TECHNIQUES | Descriptor: | INTERLEUKIN-4 | Authors: | Redfield, C, Smith, L.J, Boyd, J, Lawrence, G.M.P, Edwards, R.G, Gershater, C.J, Smith, R.A.G, Dobson, C.M. | Deposit date: | 1994-02-28 | Release date: | 1994-05-31 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Analysis of the solution structure of human interleukin-4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques. J.Mol.Biol., 238, 1994
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5TUU
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1TAC
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7Z13
| S. cerevisiae CMGE dimer nucleating origin DNA melting | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ... | Authors: | Lewis, J.S, Sousa, J.S, Costa, A. | Deposit date: | 2022-02-24 | Release date: | 2022-06-15 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanism of replication origin melting nucleated by CMG helicase assembly. Nature, 606, 2022
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